Biology:MAP3K10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.[1][2][3]
Function
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.[3]
Interactions
MAP3K10 has been shown to interact with:
References
- ↑ "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur J Biochem 234 (2): 492–500. February 1996. doi:10.1111/j.1432-1033.1995.492_b.x. PMID 8536694.
- ↑ "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene 10 (7): 1447–51. May 1995. PMID 7731697.
- ↑ 3.0 3.1 "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4294.
- ↑ 4.0 4.1 "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. January 1998. doi:10.1093/emboj/17.1.149. PMID 9427749.
- ↑ "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. June 2000. doi:10.1074/jbc.C000180200. PMID 10801775.
- ↑ 6.0 6.1 "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. October 1999. doi:10.1128/mcb.19.10.7245. PMID 10490659.
- ↑ "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proc. Natl. Acad. Sci. U.S.A. 100 (16): 9578–83. August 2003. doi:10.1073/pnas.1133382100. PMID 12881483. Bibcode: 2003PNAS..100.9578M.
Further reading
- "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. 1994. doi:10.1016/S0021-9258(17)36578-X. PMID 8195146.
- "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem. 213 (2): 701–10. 1993. doi:10.1111/j.1432-1033.1993.tb17810.x. PMID 8477742.
- "MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 272 (24): 15167–73. 1997. doi:10.1074/jbc.272.24.15167. PMID 9182538.
- "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2". J. Biol. Chem. 273 (13): 7406–12. 1998. doi:10.1074/jbc.273.13.7406. PMID 9516438.
- "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis 19 (5): 809–17. 1998. doi:10.1002/elps.1150190535. PMID 9629920.
- "Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid". Biochem. J. 335 (Pt 1): 119–24. 1998. doi:10.1042/bj3350119. PMID 9742220.
- "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. 2000. doi:10.1074/jbc.C000180200. PMID 10801775.
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95". J. Biol. Chem. 276 (14): 11382–6. 2001. doi:10.1074/jbc.M100190200. PMID 11152698.
- "The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis". Mol. Cell. Biol. 21 (14): 4713–24. 2001. doi:10.1128/MCB.21.14.4713-4724.2001. PMID 11416147.
- "CEACAM1 regulates insulin clearance in liver". Nat. Genet. 30 (3): 270–6. 2002. doi:10.1038/ng840. PMID 11850617.
- "Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking". J. Biol. Chem. 277 (39): 36280–7. 2002. doi:10.1074/jbc.M204626200. PMID 12105200.
- "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. 2004. doi:10.1074/jbc.M307357200. PMID 14504284.
- "Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors". Mol. Cell. Endocrinol. 213 (1): 71–8. 2004. doi:10.1016/j.mce.2003.10.035. PMID 15062575.
- "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. 2005. doi:10.1016/j.cub.2004.12.082. PMID 15753034.
- "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13". Anim. Genet. 37 (6): 595–6. 2007. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608.
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