Biology:HLA-DR16

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR16
Haplotypes groups DRA*01:DRB1*1601 DRA*01:DRB1*1602
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA[yes|permanent dead link|dead link}}]
EBI-HLA DRA*0101
Identifiers
beta 1 *1601 *1602 *1604
Symbol(s) HLA-DRB1[yes|permanent dead link|dead link}}]
EBI-HLA DRB1*1601
EBI-HLA DRB1*1602
EBI-HLA DRB1*1604
Shared data
Locus chr.6 6p21.31

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

Alleles

DR16, DR2 and other serotype recognition of some DRB1*16 alleles[1]
DRB1* DR16 DR2 DR15 Sample
allele % % % size (N)
1601 41 29 19 703
1602 47 30 16 239
1604 >50 1

Disease associations

DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.[5]

DRB1*1601 is associated with tuberculosis risk[6]

DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]

Extended linkage

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]

    • *1602:DQA1*0102:DQB1*0502 haplotype: graves disease,[12][13] cervical cancer (human papilloma virus infection),[14] scleroderma[10]
    • *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease,[3] systemic sclerosis[15]

Genetic Linkage

DR16 Haplotypes
Serotypes DRA DRB1 DRB5
DR16(2)-DR51 *0101 *1601 *0101
*0101 *1602 *0101
*0101 *1604 *0101
DQA1 DQB1 DRB1
DR16(2)-DQ5 (5.2, 1) *0102 *0502 *1601
HLA-A HLA-B DRB1
A2-B51(5)-DR16(2) *0201 *5101 *1601

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ "MHC class I and class II genes in Mexican patients with Chagas disease.". Hum Immunol 65 (1): 60–5. 2004. doi:10.1016/j.humimm.2003.10.008. PMID 14700597. 
  3. ↑ 3.0 3.1 3.2 "MHC class II alleles in Mexican patients with rheumatic heart disease.". Int J Cardiol 92 (1): 49–54. 2003. doi:10.1016/S0167-5273(03)00040-8. PMID 14602216. 
  4. ↑ "HLA-DR B1 and DQ B1 polymorphisms in patients with coronary artery ectasia.". Acta Cardiol 59 (5): 499–502. 2004. doi:10.2143/AC.59.5.2005222. PMID 15529553. 
  5. ↑ "Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients". Clin. Exp. Dermatol. 32 (4): 435–8. 2007. doi:10.1111/j.1365-2230.2007.02391.x. PMID 17376212. 
  6. ↑ 6.0 6.1 "Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report.". Tuberculosis (Edinb) 85 (4): 259–67. 2005. doi:10.1016/j.tube.2004.12.003. PMID 15958261. 
  7. ↑ "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol 65 (4): 359–65. 2004. doi:10.1016/j.humimm.2004.01.016. PMID 15120191. 
  8. ↑ "Association of HLA-DRB1*1602 and DRB1*1001 with in Colombian mestizos as markers of Amerindian ancestry.". Int J Cardiol 75 (Suppl 1): S113–6. 2000. doi:10.1016/s0167-5273(00)00181-9. PMID 10980348. 
  9. ↑ "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody.". Arthritis Rheum 42 (3): 465–74. 1999. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769. 
  10. ↑ 10.0 10.1 "HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis).". Tissue Antigens 53 (1): 74–80. 1999. doi:10.1034/j.1399-0039.1999.530108.x. PMID 10082433. 
  11. ↑ "HLA-DR and -DQ associations with melioidosis.". Hum Immunol 59 (9): 580–6. 1998. doi:10.1016/S0198-8859(98)00052-4. PMID 9757914. 
  12. ↑ "The association between HLA class II haplotype with Graves' disease in Thai population.". Tissue Antigens 67 (1): 79–83. 2006. doi:10.1111/j.1399-0039.2005.00498.x. PMID 16451208. 
  13. ↑ "Association of HLA-DR and -DQ genes with Graves disease in Koreans.". Hum Immunol 66 (6): 741–7. 2005. doi:10.1016/j.humimm.2005.03.001. PMID 15993720. 
  14. ↑ "HLA-DRB1*1602 allele is positively associated with HPV cervical infection in Bolivian Andean women.". Hum Immunol 64 (9): 890–5. 2003. doi:10.1016/S0198-8859(03)00163-0. PMID 12941545. 
  15. ↑ "Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype.". Arthritis Rheum 39 (8): 1362–70. 1996. doi:10.1002/art.1780390814. PMID 8702445. 



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