Biology:HLA-DR15

From HandWiki
Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR15
Haplotypes groups DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRA[yes|permanent dead link|dead link}}]
EBI-HLA DRA*0101
Identifiers
beta 1 *1501 to *1505 *1507
Symbol(s) HLA-DRB1[yes|permanent dead link|dead link}}]
EBI-HLA DRB1*1501
EBI-HLA DRB1*1502
EBI-HLA DRB1*1503
EBI-HLA DRB1*1504
EBI-HLA DRB1*1505
EBI-HLA DRB1*1507
Shared data
Locus chr.6 6p21.31

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles[1]
DRB1* DR15 DR2 DR16 Sample
allele % % % size (N)
1501 76 23 6428
1502 77 16 676
1503 81 13 286
1504 >50 1
1505 >25 2
1507 >50 1

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively associated Goodpasture syndrome,[2] early age onset multiple sclerosis,[3] pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7] and a predisposition for postmenopausal osteoporosis.[8]

DRB1*1501 is positively associated with Goodpasture syndrome,[9][10] juvenile rheumatoid arthritis,[11] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] systemic lupus erythematosus,[14] cervical cancer (human papillomavirus infection),[15] Sjögren syndrome associated with systemic lupus erythematosus,[16] and intermediate uveitis.[17]

DRB1*1502 is associated with systemic lupus erythematosus,[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.[19]

DRB1*1503 is associated with Chaga's cardiomyopathy,[20] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] cervical cancer (human papillomavirus infection).[21]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[21]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[18]

Genetic Linkage

DR15 Haplotypes
Serotypes DRA DRB1 DRB5
DR15(2)-DR51 *0101 *1501 *0101
*0101 *1502 *0101
*0101 *1503 *0101
*0101 *1504 *0101
*0101 *1505 *0101
*0101 *1507 *0101
DQA1 DQB1 DRB1
DR15(2)-DQ6(6.2, 1) *0102 *0602 *1501
DR15(2)-DQ6(6.1, 1) *0103 *0601 *1502
HLA-A HLA-B DRB1
A3-Cw7-B7-DR15(2) *0301 *0702 *1501
A1-B51-DR15(2) *0101 *5101 *1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

  1. ↑ derived from IMGT/HLA
  2. ↑ "Properties of HLA class II molecules divergently associated with Goodpasture's disease.". Int Immunol 12 (8): 1135–43. 2000. doi:10.1093/intimm/12.8.1135. PMID 10917888. 
  3. ↑ "HLA-DR15 is associated with lower age at onset in multiple sclerosis.". Annals of Neurology 48 (2): 211–9. 2000. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572. 
  4. ↑ "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed) 282 (6266): 768–70. 1981. doi:10.1136/bmj.282.6266.768. PMID 6783164. 
  5. ↑ Bilir M; Sipahi S; Yilmaz E et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393. 
  6. ↑ Hong SC; Lin L; Lo B et al. (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713. 
  7. ↑ "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. 2002. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217. 
  8. ↑ Douroudis K; Tarassi K; Athanassiades T et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269. 
  9. ↑ "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int 68 (3): 1061–70. 2005. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036. 
  10. ↑ "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int 56 (5): 1638–53. 1999. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772. 
  11. ↑ "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol 65 (4): 359–65. 2004. doi:10.1016/j.humimm.2004.01.016. PMID 15120191. 
  12. ↑ 12.0 12.1 "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc 25 (6): 395–9. 2004. PMID 15709450. 
  13. ↑ 13.0 13.1 "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens 61 (2): 166–71. 2003. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585. 
  14. ↑ "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". International Journal of Immunogenetics 32 (3): 173–8. 2005. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622. 
  15. ↑ "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet 6 (2): 157–62. 1994. doi:10.1038/ng0294-157. PMID 8162070. 
  16. ↑ "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum 50 (3): 882–91. 2004. doi:10.1002/art.20093. PMID 15022331. 
  17. ↑ Petrushkin, Harry; Thomas, Dhanes; Vaughan, Robert; Kondeatis, Elli; Stanford, Miles R.; Edelsten, Clive; Wallace, Graham R. (2015-04-01). "Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis". JAMA Ophthalmology 133 (4): 482–483. doi:10.1001/jamaophthalmol.2014.5868. ISSN 2168-6165. PMID 25634309. http://jamanetwork.com/journals/jamaophthalmology/fullarticle/2091789. 
  18. ↑ 18.0 18.1 "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens 59 (2): 113–7. 2002. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537. 
  19. ↑ "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum 42 (3): 465–74. 1999. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769. 
  20. ↑ "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem 43 (Pt 3): 214–6. 2006. doi:10.1258/000456306776865205. PMID 16704757. 
  21. ↑ 21.0 21.1 "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev 9 (11): 1183–91. 2000. PMID 11097225. 



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