Biology:HLA-DR2
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Short description: Antigen serotype
Illustration of HLA-DR
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
Serology
| DRB1* | DR15 | DR2 | DR16 | Sample |
| allele | % | % | % | size (N) |
| 15:01 | 76 | 23 | 6428 | |
| 15:02 | 77 | 16 | 676 | |
| 15:03 | 81 | 13 | 286 | |
| 15:04 | >50 | 1 | ||
| 15:05 | >25 | 2 | ||
| 15:07 | >50 | 1 | ||
| . | ||||
| DR16 | DR2 | DR15 | N | |
| 16:01 | 41 | 29 | 19 | 703 |
| 16:02 | 47 | 30 | 16 | 239 |
| 16:04 | >50 | 1 |
Disease associations
DR2 serotypes are associated with Goodpasture syndrome, systemic lupus erythematosus, multiple sclerosis,[2] and narcolepsy, tuberculoid leprosy[3] (multi-drug-resistant tuberculosis or leprosy),[4] ulcerative colitis(Japanese),[5] primary biliary cirrhosis and autoimmune hepatitis.[6] DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetase and chronic interstitial lung disease.[7]
Genetic linkage
DR2 is linked to the HLA-DR51.
References
- ↑ derived from IMGT/HLA
- ↑ "HLA family studies and multiple sclerosis: A common gene, dominantly expressed.". Hum Immunol 3 (1): 13–29. 1981. doi:10.1016/0198-8859(81)90040-9. PMID 7275697.
- ↑ "HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker.". J Infect Dis 141 (6): 693–701. 1980. doi:10.1093/infdis/141.6.693. PMID 6156220.
- ↑ "Immunogenetics of mycobacterial infections in the North Indian population". Tissue Antigens 69 (Suppl 1): 228–30. 2007. doi:10.1111/j.1399-0039.2006.77311.x. PMID 17445206.
- ↑ "Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis.". Gastroenterology 82 (3): 413–8. 1982. doi:10.1016/S0016-5085(82)80387-9. PMID 6947923.
- ↑ "HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis.". Digestion 26 (4): 213–7. 1983. doi:10.1159/000198892. PMID 6409699.
- ↑ "Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase". Arthritis Rheum. 56 (4): 1295–303. 2007. doi:10.1002/art.22506. PMID 17393393.
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