Biology:23S rRNA (adenine2503-C2,C8)-dimethyltransferase
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Short description: Obsolete enzyme family
| 23S rRNA (adenine2503-C2,C8)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.194 | ||||||||
| CAS number | 39369-30-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (adenine2503-C2,C8)-dimethyltransferase (EC 2.1.1.194, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2,C8)-dimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA [math]\displaystyle{ \rightleftharpoons }[/math] 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA
This enzyme contains an [4Fe-S] cluster.
References
- ↑ "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society 132 (11): 3953–64. March 2010. doi:10.1021/ja910850y. PMID 20184321.
- ↑ "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA 15 (2): 327–36. February 2009. doi:10.1261/rna.1371409. PMID 19144912.
- ↑ "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Research 38 (5): 1652–63. March 2010. doi:10.1093/nar/gkp1142. PMID 20007606.
External links
- 23S+rRNA+(adenine2503-C2,C8)-dimethyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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