Biology:Arsenite methyltransferase
From HandWiki
| Arsenite methyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.1.137 | ||||||||
| CAS number | 167140-41-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Arsenite methyltransferase (EC 2.1.1.137, S-adenosyl-L-methionine:arsenic(III) methyltransferase, S-adenosyl-L-methionine:methylarsonite As-methyltransferase, methylarsonite methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:arsenite As-methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + arsenite [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + methylarsonate
- (2) S-adenosyl-L-methionine + methylarsonite [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + dimethylarsinate
An enzyme of the biotransformation pathway that forms dimethylarsinate from inorganic arsenite and arsenate.
References
- ↑ "Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase". Chemical Research in Toxicology 12 (12): 1278–83. December 1999. doi:10.1021/tx9901231. PMID 10604879.
- ↑ "Enzymatic methylation of arsenic compounds. VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes". Toxicology and Applied Pharmacology 158 (1): 9–15. July 1999. doi:10.1006/taap.1999.8687. PMID 10387927.
- ↑ "Enzymatic methylation of arsenic compounds. III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic". Toxicology and Applied Pharmacology 140 (1): 77–84. September 1996. doi:10.1006/taap.1996.0199. PMID 8806872.
- ↑ "Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver". Chemical Research in Toxicology 8 (8): 1029–38. December 1995. doi:10.1021/tx00050a006. PMID 8605285.
- ↑ "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry 277 (13): 10795–803. March 2002. doi:10.1074/jbc.M110246200. PMID 11790780.
External links
- Arsenite+methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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