Biology:FKBP8

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.

Further reading

• "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo.". Electrophoresis 20 (2): 249–55. 1999. doi:10.1002/(SICI)1522-2683(19990201)20:2<249::AID-ELPS249>3.0.CO;2-F. PMID 10197430. 
• "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.". Nat. Cell Biol. 5 (1): 28–37. 2003. doi:10.1038/ncb894. PMID 12510191. 
• "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38.". Oncogene 22 (31): 4786–98. 2003. doi:10.1038/sj.onc.1206776. PMID 12894220. 
• "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G. 
• "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.". Development 131 (9): 2149–59. 2004. doi:10.1242/dev.01122. PMID 15105374. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336. 
• "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. 2005. doi:10.1038/nbt1046. PMID 15592455. 
• "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).". FEBS Lett. 579 (6): 1469–76. 2005. doi:10.1016/j.febslet.2005.01.053. PMID 15733859. 
• "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.". FEBS Lett. 579 (7): 1591–6. 2005. doi:10.1016/j.febslet.2004.12.098. PMID 15757646. 
• "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.". EMBO J. 24 (14): 2688–99. 2005. doi:10.1038/sj.emboj.7600739. PMID 15990872. 
• "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2.". Biochem. Biophys. Res. Commun. 337 (1): 30–8. 2005. doi:10.1016/j.bbrc.2005.09.023. PMID 16176796. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.