Biology:Glucose-6-phosphate exchanger SLC37A1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.[1] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[2]
Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,[3] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[4]
References
- ↑ "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1". https://www.ncbi.nlm.nih.gov/gene/54020.
- ↑ "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein". https://www.uniprot.org/uniprot/P57057.
- ↑ "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE 6 (9): e23157. 2011. doi:10.1371/journal.pone.0023157. PMID 21949678. Bibcode: 2011PLoSO...623157P.
- ↑ "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics 17 (1): 858. 2016. doi:10.1186/s12864-016-3175-3. PMID 27809761.
Further reading
- "The human sugar-phosphate/phosphate exchanger family SLC37". Pflügers Archiv 447 (5): 780–3. February 2004. doi:10.1007/s00424-003-1105-0. PMID 12811562.
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