Biology:TRNA (guanine26-N2)-dimethyltransferase
From HandWiki
| TRNA (guanine26-N2)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.216 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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TRNA (guanine26-N2)-dimethyltransferase (EC 2.1.1.216, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2)-dimethyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + guanine26 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.
References
- ↑ "Characterisation and enzymatic properties of tRNA(guanine 26, N (2), N (2))-dimethyltransferase (Trm1p) from Pyrococcus furiosus". Journal of Molecular Biology 291 (2): 375–92. August 1999. doi:10.1006/jmbi.1999.2976. PMID 10438627.
- ↑ "The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli". Nucleic Acids Research 26 (16): 3753–61. August 1998. doi:10.1093/nar/26.16.3753. PMID 9685492.
- ↑ "Point and deletion mutations eliminate one or both methyl group transfers catalysed by the yeast TRM1 encoded tRNA (m22G26)dimethyltransferase". Nucleic Acids Research 26 (22): 5102–8. November 1998. doi:10.1093/nar/26.22.5102. PMID 9801306.
- ↑ "Caenorhabditis elegans ZC376.5 encodes a tRNA (m2/2G(26))dimethyltransferance in which (246)arginine is important for the enzyme activity". Gene 226 (1): 73–81. January 1999. doi:10.1016/s0378-1119(98)00550-2. PMID 10048958.
External links
- TRNA+(guanine26-N2)-dimethyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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