Biology:Sulfur dioxygenase
From HandWiki
| Sulfur dioxygenase | |||||||||
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| Identifiers | |||||||||
| EC number | 1.13.11.18 | ||||||||
| CAS number | 37256-58-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S-sulfanylglutathione:oxygen oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
- sulfur + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] sulfite + 2 H+ (overall reaction)
- (1a) glutathione + sulfur [math]\displaystyle{ \rightleftharpoons }[/math] S-sulfanylglutathione (spontaneous reaction)
- (1b) S-sulfanylglutathione + O2 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] glutathione + sulfite + 2 H+
This enzyme contains iron.
In humans, sulfur dioxygenase is needed to detoxify sulfide.[3]
References
- ↑ "The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation 122 (1): 22–33. July 1966. doi:10.1016/0926-6593(66)90088-9. PMID 5968172.
- ↑ "The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp". Microbiology 149 (Pt 7): 1699–710. July 2003. doi:10.1099/mic.0.26212-0. PMID 12855721.
- ↑ "Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy". Nature Medicine 16 (8): 869–71. August 2010. doi:10.1038/nm.2188. PMID 20657580.
External links
- Sulfur+dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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