Biology:Lamprin
| Lamprin | |||||||||
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| Identifiers | |||||||||
| Symbol | Lamprin | ||||||||
| Pfam | PF06403 | ||||||||
| InterPro | IPR009437 | ||||||||
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In molecular biology, the lamprin family of proteins consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage.
Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY), which is present in both silk moth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution.[1]
References
- ↑ "Characterization of lamprin, an unusual matrix protein from lamprey cartilage. Implications for evolution, structure, and assembly of elastin and other fibrillar proteins". J. Biol. Chem. 268 (2): 1440–7. January 1993. doi:10.1016/S0021-9258(18)54095-3. PMID 7678258.
Further reading
- "On (GGLGY) synthetic repeating sequences of lamprin and analogous sequences.". Matrix Biol. 20 (4): 243–50. 2001. doi:10.1016/s0945-053x(01)00139-1. PMID 11470400.
- "The structure and organization of lamprin genes: multiple-copy genes with alternative splicing and convergent evolution with insect structural proteins.". Mol Biol Evol 17 (11): 1739–52. 2000. doi:10.1093/oxfordjournals.molbev.a026272. PMID 11070061.
- "The elastin-like protein matrix of lamprey branchial cartilage is cross-linked by lysyl pyridinoline.". Biochem Biophys Res Commun 261 (3): 635–40. 1999. doi:10.1006/bbrc.1999.1092. PMID 10441478.
- "Spatial and temporal distribution of lamprin mRNA during chondrogenesis of trabecular cartilage in the sea lamprey.". Anat Embryol (Berl) 193 (5): 419–26. 1996. doi:10.1007/bf00185873. PMID 8729960.
- "Detection of lamprin mRNA in the anadromous sea lamprey using in situ hybridization.". Biotech Histochem 71 (1): 44–53. 1996. doi:10.3109/10520299609117130. PMID 9138528.
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