Biology:Hydantoin racemase
From HandWiki
| Hydantoin racemase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.1.99.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Hydantoin racemase (EC 5.1.99.5, 5'-monosubstituted-hydantoin racemase, HyuA, HyuE) is an enzyme with systematic name D-5-monosubstituted-hydantoin racemase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- D-5-monosubstituted hydantoin [math]\displaystyle{ \rightleftharpoons }[/math] L-5-monosubstituted hydantoin
This enzyme is a part of the reaction cascade known as the "hydantoinase process".
References
- ↑ "Purification and characterization of the hydantoin racemase of Pseudomonas sp. strain NS671 expressed in Escherichia coli". Journal of Bacteriology 174 (24): 7989–95. December 1992. PMID 1459947.
- ↑ "Hydantoin racemase from Arthrobacter aurescens DSM 3747: heterologous expression, purification and characterization". Journal of Biotechnology 80 (3): 217–30. July 2000. doi:10.1016/s0168-1656(00)00262-5. PMID 10949312.
- ↑ "Molecular cloning, purification, and biochemical characterization of hydantoin racemase from the legume symbiont Sinorhizobium meliloti CECT 4114". Applied and Environmental Microbiology 70 (1): 625–30. January 2004. doi:10.1128/aem.70.1.625-630.2004. PMID 14711700.
- ↑ "Biochemical characterization of a novel hydantoin racemase from Agrobacterium tumefaciens C58". Biochimie 86 (2): 77–81. February 2004. doi:10.1016/j.biochi.2004.01.004. PMID 15016445. https://zenodo.org/record/890549/files/article.pdf.
- ↑ "Purification and characterization of hydantoin racemase from Microbacterium liquefaciens AJ 3912". Bioscience, Biotechnology, and Biochemistry 69 (3): 530–6. March 2005. doi:10.1271/bbb.69.530. PMID 15784981.
- ↑ "Site-directed mutagenesis indicates an important role of cysteines 76 and 181 in the catalysis of hydantoin racemase from Sinorhizobium meliloti". Protein Science 15 (12): 2729–38. December 2006. doi:10.1110/ps.062452106. PMID 17132860.
- ↑ "Hydantoinases and related enzymes as biocatalysts for the synthesis of unnatural chiral amino acids". Current Opinion in Biotechnology 12 (6): 559–63. December 2001. doi:10.1016/s0958-1669(01)00263-4. PMID 11849938.
External links
- Hydantoin+racemase at the US National Library of Medicine Medical Subject Headings (MeSH)
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