Biology:Hydrogenase (NAD+, ferredoxin)

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Hydrogenase (NAD+, ferredoxin)
Identifiers
EC number1.12.1.4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Hydrogenase (NAD+, ferredoxin) (EC 1.12.1.4, bifurcating [FeFe] hydrogenase) is an enzyme with systematic name hydrogen:NAD+, ferredoxin oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2 H2 + NAD+ + 2 oxidized ferredoxin [math]\displaystyle{ \rightleftharpoons }[/math] 5 H+ + NADH + 2 reduced ferredoxin

The enzyme from Thermotoga maritima contains a [Fe-Fe] cluster (H-cluster) and iron-sulfur clusters. I

References

  1. "The hyperthermophilic bacterium, Thermotoga maritima, contains an unusually complex iron-hydrogenase: amino acid sequence analyses versus biochemical characterization". Biochimica et Biophysica Acta 1412 (3): 212–29. August 1999. doi:10.1016/s0005-2728(99)00062-6. PMID 10482784. 
  2. "The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production". Journal of Bacteriology 191 (13): 4451–7. July 2009. doi:10.1128/JB.01582-08. PMID 19411328. 

External links