Biology:TRNA (adenine58-N1)-methyltransferase
From HandWiki
| TRNA (adenine58-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.220 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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TRNA (adenine58-N1)-methyltransferase (EC 2.1.1.220, tRNA m1A58 methyltransferase, tRNA (m1A58) methyltransferase, TrmI, tRNA (m1A58) Mtase, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine58-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + adenine58 in tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
The enzyme specifically methylates adenine58 in tRNA.
References
- ↑ "Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures". Nucleic Acids Research 31 (8): 2148–56. April 2003. doi:10.1093/nar/gkg314. PMID 12682365.
- ↑ "Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase". Nucleic Acids Research 32 (3): 1018–27. 2004. doi:10.1093/nar/gkh207. PMID 14960715.
- ↑ "The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences of the United States of America 97 (10): 5173–8. May 2000. doi:10.1073/pnas.090102597. PMID 10779558.
External links
- TRNA+(adenine58-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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