Biology:UDP-4-amino-4-deoxy-L-arabinose formyltransferase

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Short description: Class of enzymes
UDP-4-amino-4-deoxy-L-arabinose formyltransferase
Identifiers
EC number2.1.2.13
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

UDP-4-amino-4-deoxy-L-arabinose formyltransferase (EC 2.1.2.13, UDP-L-Ara4N formyltransferase, ArnAFT) is an enzyme with systematic name 10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose [math]\displaystyle{ \rightleftharpoons }[/math] 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose

The activity is part of a bifunctional enzyme that also performs the EC 1.1.1.305 reaction.

References

  1. "A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose". The Journal of Biological Chemistry 280 (14): 14154–67. April 2005. doi:10.1074/jbc.M414265200. PMID 15695810. 
  2. "Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance". Biochemistry 44 (14): 5328–38. April 2005. doi:10.1021/bi047384g. PMID 15807526. 
  3. "Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis". The Journal of Biological Chemistry 280 (24): 23000–8. June 2005. doi:10.1074/jbc.M501534200. PMID 15809294. 
  4. "Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance". Structure 13 (6): 929–42. June 2005. doi:10.1016/j.str.2005.03.018. PMID 15939024. 
  5. "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli". The Journal of Biological Chemistry 282 (49): 36077–89. December 2007. doi:10.1074/jbc.M706172200. PMID 17928292. 

External links