Biology:PRKD2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

Function

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase c. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• "Mechanism of activation of protein kinase D2(PKD2) by the CCK(B)/gastrin receptor.". J. Biol. Chem. 277 (33): 29431–6. 2002. doi:10.1074/jbc.M200934200. PMID 12058027. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists.". Biochem. Biophys. Res. Commun. 302 (4): 817–24. 2003. doi:10.1016/S0006-291X(03)00269-9. PMID 12646243. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.". Nat. Cell Biol. 6 (2): 106–12. 2004. doi:10.1038/ncb1090. PMID 14743217. 
• "Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells.". Cancer Res. 64 (24): 8939–44. 2005. doi:10.1158/0008-5472.CAN-04-0981. PMID 15604256. 
• "Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation.". J. Biol. Chem. 280 (14): 13762–70. 2005. doi:10.1074/jbc.M413396200. PMID 15623513. 
• "Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.". Mol. Biol. Cell 16 (9): 4375–85. 2006. doi:10.1091/mbc.E05-03-0251. PMID 15975900. 
• "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. 2005. doi:10.1021/pr050048h. PMID 16083285. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells.". Biochem. Biophys. Res. Commun. 348 (3): 945–9. 2006. doi:10.1016/j.bbrc.2006.07.142. PMID 16899224. 
• "Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB.". Am. J. Physiol., Cell Physiol. 292 (2): C767–77. 2007. doi:10.1152/ajpcell.00308.2006. PMID 16928771. 
• "Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells.". Int. Immunol. 18 (12): 1737–47. 2007. doi:10.1093/intimm/dxl108. PMID 17077180. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13.". Anim. Genet. 37 (6): 595–6. 2007. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608. 
• "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell. Proteomics 6 (3): 537–47. 2007. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.