Biology:16S rRNA (cytidine1409-2'-O)-methyltransferase
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Short description: Class of enzymes
| 16S rRNA (cytidine1409-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.227 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
16S rRNA (cytidine1409-2'-O)-methyltransferase (EC 2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + cytidine1409 in 16S rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
The bifunctional enzyme from Mycobacterium tuberculosis.
References
- ↑ "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Molecular Cell 23 (2): 173–82. July 2006. doi:10.1016/j.molcel.2006.05.044. PMID 16857584.
- ↑ "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy 49 (2): 571–7. February 2005. doi:10.1128/AAC.49.2.571-577.2005. PMID 15673735.
External links
- 16S+rRNA+(cytidine1409-2'-O)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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