Biology:ATPIF1
 Generic protein structure example |
ATPase inhibitor, mitochondrial is an enzyme that in humans is encoded by the ATPIF1 gene.[1][2]
This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified.[2]
It prevents ATPase from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [3] ATP synthase inhibitor forms a one-to-one complex with the F1 ATPase, possibly by binding at the alpha-beta interface. It is thought to inhibit ATP synthesis by preventing the release of ATP.[4] The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH, the inhibitor forms a dimer via antiparallel coiled coil interactions between the C-terminal regions of two monomers. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity.[3]
| Mitochondrial ATPase inhibitor, IATP | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 c-terminal coiled-coil domain from bovine if1 | |||||||||
| Identifiers | |||||||||
| Symbol | IATP | ||||||||
| Pfam | PF04568 | ||||||||
| InterPro | IPR007648 | ||||||||
| SCOP2 | 1hf9 / SCOPe / SUPFAM | ||||||||
| |||||||||
References
- ↑ "Nucleotide sequence of cDNA coding the mitochondrial precursor protein of the ATPase inhibitor from humans". Biosci Biotechnol Biochem 63 (12): 2225–2227. Mar 2000. doi:10.1271/bbb.63.2225. PMID 10664857.
- ↑ 2.0 2.1 "Entrez Gene: ATPIF1 ATPase inhibitory factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93974.
- ↑ 3.0 3.1 "Homologous and heterologous inhibitory effects of ATPase inhibitor proteins on F-ATPases". J. Biol. Chem. 277 (44): 41334–41. November 2002. doi:10.1074/jbc.M207169200. PMID 12186878. http://grupos.unican.es/intergenomica/docencia/pdfs/Cabezon02.pdf.
- ↑ "The ATPase inhibitor protein from bovine heart mitochondria: the minimal inhibitory sequence". Biochemistry 35 (49): 15618–25. December 1996. doi:10.1021/bi960628f. PMID 8961923.
External links
- Human ATPIF1 genome location and ATPIF1 gene details page in the UCSC Genome Browser.
Further reading
- "The structure of bovine IF(1), the regulatory subunit of mitochondrial F-ATPase". EMBO J. 20 (24): 6990–6996. 2002. doi:10.1093/emboj/20.24.6990. PMID 11742976.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMID 15489334.
- Burwick NR; Wahl ML; Fang J et al. (2005). "An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface". J. Biol. Chem. 280 (3): 1740–1745. doi:10.1074/jbc.M405947200. PMID 15528193.
- Andersen JS; Lam YW; Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- Cortés-Hernández P; Domínguez-Ramírez L; Estrada-Bernal A et al. (2005). "The inhibitor protein of the F1F0-ATP synthase is associated to the external surface of endothelial cells". Biochem. Biophys. Res. Commun. 330 (3): 844–849. doi:10.1016/j.bbrc.2005.03.064. PMID 15809073.
- Lim J; Hao T; Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Ma J; Dempsey AA; Stamatiou D et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
- Contessi S; Comelli M; Cmet S et al. (2008). "IF(1) distribution in HepG2 cells in relation to ecto-F(0)F (1)ATPsynthase and calmodulin". J. Bioenerg. Biomembr. 39 (4): 291–300. doi:10.1007/s10863-007-9091-0. PMID 17851741.
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