Biology:ADAM9

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

Interactions

ADAM9 has been shown to interact with:

• MAD2L2,
• SH3GL2, and
• SNX9

Further reading

• "A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions". Cancer Res. 65 (11): 4728–38. June 2005. doi:10.1158/0008-5472.CAN-04-4449. PMID 15930291. 
• "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. 1995. doi:10.1093/dnares/1.1.27. PMID 7584026. 
• "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. 1995. doi:10.1093/dnares/1.1.47. PMID 7584028. 
• "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.". Biochem. J. 318 (2): 459–62. 1996. doi:10.1042/bj3180459. PMID 8809033. 
• "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes.". Biochem. Biophys. Res. Commun. 230 (2): 335–9. 1997. doi:10.1006/bbrc.1996.5957. PMID 9016778. 
• "A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.". EMBO J. 17 (24): 7260–72. 1999. doi:10.1093/emboj/17.24.7260. PMID 9857183. 
• "Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.". J. Biol. Chem. 274 (6): 3531–40. 1999. doi:10.1074/jbc.274.6.3531. PMID 9920899. 
• "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.". Biochem. J. 343 (3): 673–80. 2000. doi:10.1042/0264-6021:3430673. PMID 10527948. 
• "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693–9. 1999. doi:10.1074/jbc.274.44.31693. PMID 10531379. 
• "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin.". Biochem. Biophys. Res. Commun. 280 (2): 574–80. 2001. doi:10.1006/bbrc.2000.4155. PMID 11162558. 
• "Involvement of ADAM9 in multinucleated giant cell formation of blood monocytes.". Cell. Immunol. 213 (2): 104–13. 2002. doi:10.1006/cimm.2001.1873. PMID 11831872. 
• "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions.". J. Biol. Chem. 277 (20): 17804–10. 2002. doi:10.1074/jbc.M200086200. PMID 11882657. 
• "Downregulated expression of ADAM9 in anterior polar cataracts.". Journal of Cataract and Refractive Surgery 28 (4): 697–702. 2002. doi:10.1016/S0886-3350(01)01236-6. PMID 11955914. 
• "A secreted form of human ADAM9 has an alpha-secretase activity for APP.". Biochem. Biophys. Res. Commun. 293 (2): 800–5. 2002. doi:10.1016/S0006-291X(02)00302-9. PMID 12054541. 
• "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs.". FEBS Lett. 524 (1–3): 154–8. 2002. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "ADAM-9 is an insulin-like growth factor binding protein-5 protease produced and secreted by human osteoblasts". Biochemistry 41 (51): 15394–403. 2003. doi:10.1021/bi026458q. PMID 12484779. 
• "Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase". Biochem. Biophys. Res. Commun. 301 (1): 231–5. 2003. doi:10.1016/S0006-291X(02)02999-6. PMID 12535668. 
• "Expression of ADAM-9 mRNA and protein in human breast cancer". Int. J. Cancer 105 (6): 754–61. 2003. doi:10.1002/ijc.11161. PMID 12767059. 
• "ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma". Br. J. Cancer 90 (5): 1053–8. 2004. doi:10.1038/sj.bjc.6601645. PMID 14997207. 

External links

• ADAM9 on the Atlas of Genetics and Oncology
• Human ADAM9 genome location and ADAM9 gene details page in the UCSC Genome Browser.