Biology:Genetically modified canola

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Short description: Genetically modified crop


Genetically modified canola is a genetically modified crop. The first strain, Roundup Ready canola, was developed by Monsanto for tolerance to glyphosate, the active ingredient in the commonly used herbicide Roundup.

Genetic modification

Glyphosate is a broad-spectrum herbicide, which is used to kill weeds and grasses which are known to compete with commercial crops grown around the world. The first product came onto the market in the 1970's under the name ‘Roundup’. Plants which are exposed to glyphosate are unable to produce aromatic amino acids and in turn die.[1]

To produce the Roundup Ready canola, two genes were introduced into the canola genome. One is a gene derived from the common soil bacterium Agrobacterium strain CP4, that encodes for the EPSPS enzyme. The other is a gene from the Brucella anthropi strain LBAA, which encodes for the enzyme glyphosate oxidase (GOX). The CP4 EPSPS enzyme imparts high tolerance to glyphosate, so the plants can still create aromatic amino acids even after glyphosate is applied. GOX helps break down glyphosate within the plant.[2]

Regulation

Genetically modified crops undergo a significant amount of regulation throughout the world.

For a GM crop to be approved for release in the US, it must be assessed by the Animal and Plant Health Inspection Service (APHIS) agency within the US Department of Agriculture (USDA) and may also be assessed by the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA), depending on the intended use. The USDA evaluates the plant's potential to become a weed. The FDA regulates crops used as food or animal feed.[3][4] In Canada , the largest producer of GM canola,[5] GM crops are regulated by Health Canada, under the Food and Drugs Act, and the Canadian Food Inspection Agency[6] are responsible for evaluating the safety and nutritional value of genetically modified foods. Environmental assessments of biotechnology-derived plants are carried out by the CFIA's Plant Biosafety Office (PBO).[7] Glyphosate- and glufosinate-tolerant canola were the first two GM plants to gain approval in Canada.[8] In Australia Roundup Ready Canola was approved for commercial production in 2003 by the Gene Technology Regulator after undergoing approximately 400 tests and studies to determine it was safe. Food Standards Australia New Zealand also approved this product as being safe for human consumption in the same year.[9]

Controversy

Main page: Philosophy:Genetically modified food controversies

Controversy exists over the use of food and other goods derived from genetically modified crops instead of from conventional crops, and other uses of genetic engineering in food production. The dispute involves consumers, biotechnology companies, governmental regulators, nongovernmental organizations, and scientists. The key areas of controversy related to GMO foods are whether they should be labeled, the role of government regulators, the objectivity of scientific research and publication, the effect of GM crops on health and the environment, the effect on pesticide resistance, the impact of GM crops for farmers, and the role of GM crops in feeding the world population.

There is a scientific consensus[10][11][12][13] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[14][15][16][17][18] but that each GM food needs to be tested on a case-by-case basis before introduction.[19][20][21] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[22][23][24][25] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[26][27][28][29]

Advocacy groups such as Greenpeace, the Non-GMO Project, and Organic Consumers Association say that risks of GM food have not been adequately identified and managed, and have questioned the objectivity of regulatory authorities. They have expressed concerns about the objectivity of regulators and rigor of the regulatory process, about contamination of the non-GM food supply,[30] about effects of GMOs on the environment and nature, and about the consolidation of control of the food supply in companies that make and sell GMOs.[31]

Resistances problems

Due to the heavy reliance of glyphosate in agriculture, resistance to this chemical is a problem and is prevalent throughout Australia, the USA, and Canada.[32][33]

Roundup canola has also emerged as a weed in other crops due to its glyphosate resistance. This is due to canola seed being able to be dormant in the soil for up to 10 years. In California, it has become a significant problem in this way because of the restrictions on phenoxy herbicides being used in the state due to crops such as the sensitivity of cotton and grapes to this chemical.[34]

References

  1. ↑ "Glyphosate". orst.edu. http://npic.orst.edu/factsheets/archive/glyphotech.html. 
  2. ↑ Monsanto. "What is Roundup Ready canola?". http://www.monsanto.com/global/au/products/Documents/tech-topic-what-is-roundup-ready-canola.pdf. 
  3. ↑ "Questions & Answers on Food from Genetically Engineered Plants". fda.gov. https://www.fda.gov/Food/FoodScienceResearch/Biotechnology/ucm346030.htm. 
  4. ↑ "FDA page on Regulation of GM Plants in Animal Feed". https://www.fda.gov/AnimalVeterinary/NewsEvents/FDAVeterinarianNewsletter/ucm133247.htm. 
  5. ↑ GMO Compass Rapeseed 27 July 2010. Retrieved 6 August 2010.
  6. ↑ Government of Canada, Canadian Food Inspection Agency (20 March 2015). "Plants with novel traits: Information for the general public". https://inspection.canada.ca/plant-varieties/plants-with-novel-traits/general-public/eng/1337380923340/1337384231869. 
  7. ↑ "Genetically Modified Food.". http://www.thecanadianencyclopedia.com/articles/genetically-modified-foods.. 
  8. ↑ Biden, Scott; Smyth, Stuart J.; Hudson, David (2018-01-02). "The economic and environmental cost of delayed GM crop adoption: The case of Australia's GM canola moratorium". GM Crops & Food (Taylor & Francis) 9 (1): 13–20. doi:10.1080/21645698.2018.1429876. ISSN 2164-5698. PMID 29359993. 
  9. ↑ "Fact Sheet - GMOs approved for commercial release in Australia: GM Canola". Australian Government. http://ogtr.gov.au/internet/ogtr/publishing.nsf/Content/factcanolaApr10-htm. 
  10. ↑ Nicolia, Alessandro; Manzo, Alberto; Veronesi, Fabio; Rosellini, Daniele (2013). "An overview of the last 10 years of genetically engineered crop safety research". Critical Reviews in Biotechnology 34 (1): 77–88. doi:10.3109/07388551.2013.823595. PMID 24041244. https://www.pps.net/cms/lib/OR01913224/Centricity/Domain/3337/peer%20reviewed%20meta%20study%20on%20GMOs%20copy.pdf. "We have reviewed the scientific literature on GE crop safety for the last 10 years that catches the scientific consensus matured since GE plants became widely cultivated worldwide, and we can conclude that the scientific research conducted so far has not detected any significant hazard directly connected with the use of GM crops.

    The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.".     
  11. ↑ "State of Food and Agriculture 2003–2004. Agricultural Biotechnology: Meeting the Needs of the Poor. Health and environmental impacts of transgenic crops". Food and Agriculture Organization of the United Nations. http://www.fao.org/docrep/006/Y5160E/y5160e10.htm#P3_1651The. "Currently available transgenic crops and foods derived from them have been judged safe to eat and the methods used to test their safety have been deemed appropriate. These conclusions represent the consensus of the scientific evidence surveyed by the ICSU (2003) and they are consistent with the views of the World Health Organization (WHO, 2002). These foods have been assessed for increased risks to human health by several national regulatory authorities (inter alia, Argentina, Brazil, Canada, China, the United Kingdom and the United States) using their national food safety procedures (ICSU). To date no verifiable untoward toxic or nutritionally deleterious effects resulting from the consumption of foods derived from genetically modified crops have been discovered anywhere in the world (GM Science Review Panel). Many millions of people have consumed foods derived from GM plants - mainly maize, soybean and oilseed rape - without any observed adverse effects (ICSU)." 
  12. ↑ Ronald, Pamela (May 1, 2011). "Plant Genetics, Sustainable Agriculture and Global Food Security". Genetics 188 (1): 11–20. doi:10.1534/genetics.111.128553. PMID 21546547. ""There is broad scientific consensus that genetically engineered crops currently on the market are safe to eat. After 14 years of cultivation and a cumulative total of 2 billion acres planted, no adverse health or environmental effects have resulted from commercialization of genetically engineered crops (Board on Agriculture and Natural Resources, Committee on Environmental Impacts Associated with Commercialization of Transgenic Plants, National Research Council and Division on Earth and Life Studies 2002). Both the U.S. National Research Council and the Joint Research Centre (the European Union's scientific and technical research laboratory and an integral part of the European Commission) have concluded that there is a comprehensive body of knowledge that adequately addresses the food safety issue of genetically engineered crops (Committee on Identifying and Assessing Unintended Effects of Genetically Engineered Foods on Human Health and National Research Council 2004; European Commission Joint Research Centre 2008). These and other recent reports conclude that the processes of genetic engineering and conventional breeding are no different in terms of unintended consequences to human health and the environment (European Commission Directorate-General for Research and Innovation 2010)."". 
  13. ↑

    But see also:

    Domingo, José L.; Bordonaba, Jordi Giné (2011). "A literature review on the safety assessment of genetically modified plants". Environment International 37 (4): 734–742. doi:10.1016/j.envint.2011.01.003. PMID 21296423. http://gaiapresse.ca/images/nouvelles/28563.pdf. "In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as the respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents a notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies.". 

    Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment". Science, Technology, & Human Values 40 (6): 883–914. doi:10.1177/0162243915598381. "I began this article with the testimonials from respected scientists that there is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story.". 

    And contrast:

    Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology 37 (2): 213–217. doi:10.3109/07388551.2015.1130684. ISSN 0738-8551. PMID 26767435. "Here, we show that a number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm.

    The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken the evidence for the harm and lack of substantial equivalency of studied GMOs. We emphasize that with over 1783 published articles on GMOs over the last 10 years it is expected that some of them should have reported undesired differences between GMOs and conventional crops even if no such differences exist in reality.".     

    and

    Yang, Y.T.; Chen, B. (2016). "Governing GMOs in the USA: science, law and public health". Journal of the Science of Food and Agriculture 96 (4): 1851–1855. doi:10.1002/jsfa.7523. PMID 26536836. Bibcode: 2016JSFA...96.1851Y. "It is therefore not surprising that efforts to require labeling and to ban GMOs have been a growing political issue in the USA (citing Domingo and Bordonaba, 2011). Overall, a broad scientific consensus holds that currently marketed GM food poses no greater risk than conventional food... Major national and international science and medical associations have stated that no adverse human health effects related to GMO food have been reported or substantiated in peer-reviewed literature to date.

    Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.".     
  14. ↑ "Statement by the AAAS Board of Directors On Labeling of Genetically Modified Foods". American Association for the Advancement of Science. October 20, 2012. http://www.aaas.org/sites/default/files/AAAS_GM_statement.pdf. ""The EU, for example, has invested more than €300 million in research on the biosafety of GMOs. Its recent report states: "The main conclusion to be drawn from the efforts of more than 130 research projects, covering a period of more than 25 years of research and involving more than 500 independent research groups, is that biotechnology, and in particular GMOs, are not per se more risky than e.g. conventional plant breeding technologies." The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: consuming foods containing ingredients derived from GM crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques."" 

    Pinholster, Ginger (October 25, 2012). "AAAS Board of Directors: Legally Mandating GM Food Labels Could "Mislead and Falsely Alarm Consumers"". American Association for the Advancement of Science. https://www.aaas.org/sites/default/files/AAAS_GM_statement.pdf. 
  15. ↑ European Commission. Directorate-General for Research (2010). A decade of EU-funded GMO research (2001–2010). Directorate-General for Research and Innovation. Biotechnologies, Agriculture, Food. European Commission, European Union.. doi:10.2777/97784. ISBN 978-92-79-16344-9. http://ec.europa.eu/research/biosociety/pdf/a_decade_of_eu-funded_gmo_research.pdf. Retrieved August 30, 2019. 
  16. ↑ "AMA Report on Genetically Modified Crops and Foods (online summary)". American Medical Association. January 2001. https://www.isaaa.org/kc/Publications/htm/articles/Position/ama.htm. ""A report issued by the scientific council of the American Medical Association (AMA) says that no long-term health effects have been detected from the use of transgenic crops and genetically modified foods, and that these foods are substantially equivalent to their conventional counterparts. (from online summary prepared by ISAAA)" "Crops and foods produced using recombinant DNA techniques have been available for fewer than 10 years and no long-term effects have been detected to date. These foods are substantially equivalent to their conventional counterparts.

    (from original report by AMA: [1])""     "REPORT 2 OF THE COUNCIL ON SCIENCE AND PUBLIC HEALTH (A-12): Labeling of Bioengineered Foods". American Medical Association. 2012. http://www.ama-assn.org/resources/doc/csaph/a12-csaph2-bioengineeredfoods.pdf. "Bioengineered foods have been consumed for close to 20 years, and during that time, no overt consequences on human health have been reported and/or substantiated in the peer-reviewed literature." 
  17. ↑ "Restrictions on Genetically Modified Organisms: United States. Public and Scholarly Opinion". Library of Congress. June 30, 2015. http://www.loc.gov/law/help/restrictions-on-gmos/usa.php#Opinion. ""Several scientific organizations in the US have issued studies or statements regarding the safety of GMOs indicating that there is no evidence that GMOs present unique safety risks compared to conventionally bred products. These include the National Research Council, the American Association for the Advancement of Science, and the American Medical Association. Groups in the US opposed to GMOs include some environmental organizations, organic farming organizations, and consumer organizations. A substantial number of legal academics have criticized the US's approach to regulating GMOs."" 
  18. ↑ National Academies Of Sciences, Engineering; Division on Earth Life Studies; Board on Agriculture Natural Resources; Committee on Genetically Engineered Crops: Past Experience Future Prospects (2016). Genetically Engineered Crops: Experiences and Prospects. The National Academies of Sciences, Engineering, and Medicine (US). p. 149. doi:10.17226/23395. ISBN 978-0-309-43738-7. http://www.nap.edu/read/23395/chapter/7#149. Retrieved August 30, 2019. ""Overall finding on purported adverse effects on human health of foods derived from GE crops: On the basis of detailed examination of comparisons of currently commercialized GE with non-GE foods in compositional analysis, acute and chronic animal toxicity tests, long-term data on health of livestock fed GE foods, and human epidemiological data, the committee found no differences that implicate a higher risk to human health from GE foods than from their non-GE counterparts."" 
  19. ↑ "Frequently asked questions on genetically modified foods". World Health Organization. https://www.who.int/foodsafety/areas_work/food-technology/faq-genetically-modified-food/en/. "Different GM organisms include different genes inserted in different ways. This means that individual GM foods and their safety should be assessed on a case-by-case basis and that it is not possible to make general statements on the safety of all GM foods.

    GM foods currently available on the international market have passed safety assessments and are not likely to present risks for human health. In addition, no effects on human health have been shown as a result of the consumption of such foods by the general population in the countries where they have been approved. Continuous application of safety assessments based on the Codex Alimentarius principles and, where appropriate, adequate post market monitoring, should form the basis for ensuring the safety of GM foods."     
  20. ↑ Haslberger, Alexander G. (2003). "Codex guidelines for GM foods include the analysis of unintended effects". Nature Biotechnology 21 (7): 739–741. doi:10.1038/nbt0703-739. PMID 12833088. "These principles dictate a case-by-case premarket assessment that includes an evaluation of both direct and unintended effects.". 
  21. ↑ Some medical organizations, including the British Medical Association, advocate further caution based upon the precautionary principle:

    "Genetically modified foods and health: a second interim statement". British Medical Association. March 2004. http://www.argenbio.org/adc/uploads/pdf/bma.pdf. "In our view, the potential for GM foods to cause harmful health effects is very small and many of the concerns expressed apply with equal vigour to conventionally derived foods. However, safety concerns cannot, as yet, be dismissed completely on the basis of information currently available.

    When seeking to optimise the balance between benefits and risks, it is prudent to err on the side of caution and, above all, learn from accumulating knowledge and experience. Any new technology such as genetic modification must be examined for possible benefits and risks to human health and the environment. As with all novel foods, safety assessments in relation to GM foods must be made on a case-by-case basis.

    Members of the GM jury project were briefed on various aspects of genetic modification by a diverse group of acknowledged experts in the relevant subjects. The GM jury reached the conclusion that the sale of GM foods currently available should be halted and the moratorium on commercial growth of GM crops should be continued. These conclusions were based on the precautionary principle and lack of evidence of any benefit. The Jury expressed concern over the impact of GM crops on farming, the environment, food safety and other potential health effects.

    The Royal Society review (2002) concluded that the risks to human health associated with the use of specific viral DNA sequences in GM plants are negligible, and while calling for caution in the introduction of potential allergens into food crops, stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares the view that there is no robust evidence to prove that GM foods are unsafe but we endorse the call for further research and surveillance to provide convincing evidence of safety and benefit."     
  22. ↑ Funk, Cary; Rainie, Lee (January 29, 2015). "Public and Scientists' Views on Science and Society". Pew Research Center. http://www.pewinternet.org/2015/01/29/public-and-scientists-views-on-science-and-society/. "The largest differences between the public and the AAAS scientists are found in beliefs about the safety of eating genetically modified (GM) foods. Nearly nine-in-ten (88%) scientists say it is generally safe to eat GM foods compared with 37% of the general public, a difference of 51 percentage points." 
  23. ↑ Marris, Claire (2001). "Public views on GMOs: deconstructing the myths". EMBO Reports 2 (7): 545–548. doi:10.1093/embo-reports/kve142. PMID 11463731. 
  24. ↑ Final Report of the PABE research project (December 2001). "Public Perceptions of Agricultural Biotechnologies in Europe". Commission of European Communities. http://csec.lancs.ac.uk/archive/pabe/docs/pabe_finalreport.doc. 
  25. ↑ Scott, Sydney E.; Inbar, Yoel; Rozin, Paul (2016). "Evidence for Absolute Moral Opposition to Genetically Modified Food in the United States". Perspectives on Psychological Science 11 (3): 315–324. doi:10.1177/1745691615621275. PMID 27217243. http://yoelinbar.net/papers/gmo_absolute.pdf. 
  26. ↑ "Restrictions on Genetically Modified Organisms". Library of Congress. June 9, 2015. http://www.loc.gov/law/help/restrictions-on-gmos/. 
  27. ↑ Bashshur, Ramona (February 2013). "FDA and Regulation of GMOs". American Bar Association. http://www.americanbar.org/content/newsletter/publications/aba_health_esource_home/aba_health_law_esource_1302_bashshur.html. 
  28. ↑ Sifferlin, Alexandra (October 3, 2015). "Over Half of E.U. Countries Are Opting Out of GMOs". Time. http://time.com/4060476/eu-gmo-crops-european-union-opt-out/. Retrieved August 30, 2019. 
  29. ↑ Lynch, Diahanna; Vogel, David (April 5, 2001). "The Regulation of GMOs in Europe and the United States: A Case-Study of Contemporary European Regulatory Politics". Council on Foreign Relations. http://www.cfr.org/agricultural-policy/regulation-gmos-europe-united-states-case-study-contemporary-european-regulatory-politics/p8688. 
  30. ↑ Paull, John (2019) Contamination of Farms by Genetically Modified Organisms (GMOs): Options for Compensation, Journal of Organics, 6(1):31-46.
  31. ↑ "Monsanto ready to defend roundup ready canola". The Star Phoenix. 26 October 2004. ProQuest 348860116. 
  32. ↑ "Resisting Roundup". The New York Times. 16 May 2010. https://www.nytimes.com/2010/05/17/opinion/17mon3.html?ref=opinion. 
  33. ↑ Preston, Chris (January 2010). "Roundup Ready Canola and Glyphosate Resistance". Australian Grain 19: 6–7. http://search.informit.com.au.ezproxy1.library.usyd.edu.au/fullText;dn=322612245978495;res=IELHSS. Retrieved 8 November 2013. 
  34. ↑ Munier, Douglas; Brittan, Kent; UC Farm Advisors (December 2010). "Roundup ready canola as a resistant weed". Western Farm Press. http://westernfarmpress.com/management/roundup-ready-canola-resistant-weed. Retrieved 8 November 2013. 



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