Medicine:Hepatitis B vaccine

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Short description: Vaccine against hepatitis B
Hepatitis B vaccine
Engerix B (Hepatitis B) vaccine.jpg
Hepatitis B vaccine
Vaccine description
Target diseaseHepatitis B virus
TypeSubunit
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Trade namesRecombivax HB, Engerix-B, Heplisav-B, others
AHFS/Drugs.comMonograph
MedlinePlusa607014
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administration		Intramuscular (IM)
Drug classAntiviral
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Hepatitis B vaccine is a vaccine that prevents hepatitis B.[13] The first dose is recommended within 24 hours of birth with either two or three more doses given after that.[13] This includes those with poor immune function such as from HIV/AIDS and those born premature.[13] It is also recommended that health-care workers be vaccinated.[14] In healthy people, routine immunization results in more than 95% of people being protected.[13]

Blood testing to verify that the vaccine has worked is recommended in those at high risk.[13] Additional doses may be needed in people with poor immune function but are not necessary for most people.[13] In those who have been exposed to the hepatitis B virus (HBV) but not immunized, hepatitis B immune globulin should be given in addition to the vaccine.[13] The vaccine is given by injection into a muscle.[13]

Serious side effects from the hepatitis B vaccine are very uncommon.[13] Pain may occur at the site of injection.[13] It is safe for use during pregnancy or while breastfeeding.[13] It has not been linked to Guillain–Barré syndrome.[13] Hepatitis B vaccines are produced with recombinant DNA techniques and contain immunologic adjuvant.[13] They are available both by themselves and in combination with other vaccines.[13]

The first hepatitis B vaccine was approved in the United States in 1981.[15] A recombinant version came to market in 1986.[13] It is on the World Health Organization's List of Essential Medicines.[16][17] Both versions were developed by Maurice Hilleman and his team.[18][19][20]

Medical uses

In the United States vaccination is recommended for nearly all babies at birth.[21] Many countries routinely vaccinate infants against hepatitis B. In countries with high rates of hepatitis B infection, vaccination of newborns has not only reduced the risk of infection, but has also led to a marked reduction in liver cancer. This was reported in Taiwan where the implementation of a nationwide hepatitis B vaccination program in 1984 was associated with a decline in the incidence of childhood hepatocellular carcinoma.[22]

In the UK, the vaccine is offered to men who have sex with men (MSM), usually as part of a sexual health check-up. A similar situation is in operation in Ireland.[23]

In many areas, vaccination against hepatitis B is also required for all health-care and laboratory staff.[24] Both types of the vaccine, the plasma-derived vaccine (PDV) and recombinant vaccine (RV), seems to be able to elicit similar protective anti-HBs levels.[14]

The US Centers for Disease Control and Prevention (CDC) issued recommendations for vaccination against hepatitis B among patients with diabetes mellitus.[25] The World Health Organization (WHO) recommends a pentavalent vaccine, combining vaccines against diphtheria, tetanus, pertussis and Haemophilus influenzae type B with the vaccine against hepatitis B. There is not yet sufficient evidence on how effective this pentavalent vaccine is in relation to the individual vaccines.[26] A pentavalent vaccine combining vaccines against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis is approved in the U.S. and is recommended by the Advisory Committee on Immunization Practices (ACIP).[27][28][29]

Hepatitis B vaccination, hepatitis B immunoglobulin, and the combination of hepatitis B vaccine plus hepatitis B immunoglobulin, all are considered as preventive for babies born to mothers infected with hepatitis B virus (HBV).[30] The combination is superior for protecting these infants.[30] The vaccine during pregnancy is not considered to be valuable in protecting babies of the infected mothers.[31] Hepatitis B immunoglobulin before birth has not been well studied.[32]

Effectiveness

Studies have found that that immune memory against HepB is sustained for at least 30 years after vaccination, and protects against clinical disease and chronic HepB infection, even in cases where anti-hepatitis B surface antigen (anti-Hbs) levels decline below detectable levels.[33] Testing to confirm successful immunization or sustained immunity is not necessary or recommended for most people, but is recommended for infants born to a mother who tests positive for HBsAg or whose HBsAg status is not known; for healthcare and public safety workers; for immunocompromised people such as haemodialysis patients, HIV patients, haematopoietic stem cell transplant [HSCT] recipients, or people receiving chemotherapy; and for sexual partners of HBsAg-positive people.[33]

An anti-Hbs antibody level above 100 mIU/ml is deemed adequate, and occurs in about 85–90% of individuals.[34] An antibody level between 10 and 100 mIU/ml is considered a poor response, and these people should receive a single booster vaccination at this time, but do not need further retesting.[34] People who fail to respond (anti-Hbs antibody level below 10 mIU/ml) should be tested to exclude current or past hepatitis B infection, and given a repeat course of three vaccinations, followed by further retesting 1–4 months after the second course. Those who still do not respond to a second course of vaccination may respond to intradermal injection[35] or to a high dose vaccine[36] or to a double dose of a combined hepatitis A and B vaccine.[37] Those who still fail to respond will require hepatitis B immunoglobulin (HBIG) if later exposed to the hepatitis B virus.[34]

Poor responses are mostly associated with being over the age of 40 years, obesity, celiac disease, and tobacco smoking,[35][38] and also in alcoholics, especially if with advanced liver disease.[39] People who are immunosuppressed or on dialysis may not respond as well and require larger or more frequent doses of vaccine.[34] At least one study suggests that hepatitis B vaccination is less effective in patients with HIV.[40]

Duration of protection

Hepatitis B vaccine is now believed to provide indefinite protection. Older literature assumed that immunity would wane with antibody titers and only effectively last five to seven years,[41][42] but immune-challenge studies show that even after 30 years, the immune system maintains the ability to produce an anamnestic response, i.e. to rapidly bump up antibody levels when the previously seen antigen is detected.[43][44] This shows that the immunological memory is not affected by the loss of antibody levels. As a result, subsequent antibody testing and administration of booster doses is not required in successfully vaccinated immunocompetent individuals.[45][46] UK guidelines suggest that people who respond to the vaccine and are at risk of occupational exposure, such as for healthcare workers, a single booster is recommended five years after initial immunization.[34]

Side effects

Serious side effects from the hepatitis B vaccine are very rare.[13] Pain may occur at the site of injection.[13] It is generally considered safe for use, during pregnancy or while breastfeeding.[13][47] It has not been linked to Guillain–Barré syndrome.[13]

Multiple sclerosis

Several studies have looked for an association between recombinant hepatitis B vaccine and multiple sclerosis (MS) in adults.[48] Most studies do not support a causal relationship between hepatitis B vaccination and demyelinating diseases such as MS.[48][49][50] A 2004 study reported a significant increase in risk within three years of vaccination. Some of these studies were criticized for methodological problems.[51] This controversy created public misgivings about hepatitis B vaccination, and hepatitis B vaccination in children remained low in several countries. A 2006 study concluded that evidence did not support an association between hepatitis B vaccination and sudden infant death syndrome, chronic fatigue syndrome, or multiple sclerosis.[52] A 2007 study found that the vaccination does not seem to increase the risk of a first episode of MS in childhood.[53] Hepatitis B vaccination has not been linked to onset of autoimmune diseases in adulthood.[54]

Usage

Share of one-year-olds vaccinated against hepatitis B, 2017[55]

The following is a list of countries by the percentage of infants receiving three doses of hepatitis B vaccine as published by the World Health Organization (WHO) in 2017.[56]

Hepatitis B (HepB3) immunization coverage
among one-year-olds worldwide
Country Coverage %
Afghanistan 65
Albania 99
Algeria 91
Andorra 98
Angola 52
Antigua and Barbuda 95
Argentina 86
Armenia 94
Australia 95
Austria 90
Azerbaijan 95
Bahamas 94
Bahrain 98
Bangladesh 97
Barbados 90
Belarus 98
Belgium 97
Belize 88
Benin 82
Bhutan 98
Bolivia (Plurinational State of) 83
Bosnia and Herzegovina 77
Botswana 95
Brazil 93
Brunei Darussalam 99
Bulgaria 92
Burkina Faso 91
Burundi 91
Côte d'Ivoire 84
Cabo Verde 86
Cambodia 93
Cameroon 86
Canada 69
Central African Republic 47
Chad 41
Chile 93
China 99
Colombia 92
Comoros 91
Congo 69
Cook Islands 99
Costa Rica 97
Croatia 94
Cuba 99
Cyprus 97
Czech Republic 94
Democratic People's Republic of Korea 97
Democratic Republic of the Congo 81
Djibouti 68
Dominica 91
Dominican Republic 81
Ecuador 84
Egypt 94
El Salvador 85
Equatorial Guinea 25
Eritrea 95
Estonia 92
Eswatini 90
Ethiopia 73
Fiji 99
France 90
Gabon 75
Gambia 92
Georgia 91
Germany 87
Ghana 99
Greece 96
Grenada 96
Guatemala 82
Guinea 45
Guinea-Bissau 87
Guyana 97
Haiti 58
Honduras 97
India 88
Indonesia 79
Iran (Islamic Republic of) 99
Iraq 63
Ireland 95
Israel 97
Italy 94
Jamaica 93
Jordan 99
Kazakhstan 99
Kenya 82
Kiribati 90
Kuwait 99
Kyrgyzstan 92
Lao People's Democratic Republic 85
Latvia 98
Lebanon 78
Lesotho 93
Liberia 86
Libya 94
Lithuania 94
Luxembourg 94
Macedonia 91
Madagascar 74
Malawi 88
Malaysia 98
Maldives 99
Mali 66
Malta 88
Marshall Islands 82
Mauritania 81
Mauritius 96
Mexico 93
Micronesia (Federated States of) 80
Monaco 99
Mongolia 99
Montenegro 73
Morocco 99
Mozambique 80
Myanmar 89
Namibia 88
Nauru 87
Nepal 90
Netherlands 92
New Zealand 94
Nicaragua 98
Niger 81
Nigeria 42
Niue 99
Oman 99
Pakistan 75
Palau 98
Panama 81
Papua New Guinea 56
Paraguay 91
Peru 83
Philippines 88
Poland 95
Portugal 98
Qatar 97
Republic of Korea 98
Republic of Moldova 89
Romania 92
Russian Federation 97
Rwanda 98
Saint Kitts and Nevis 98
Saint Lucia 80
Saint Vincent and the Grenadines 99
Samoa 73
San Marino 86
São Tomé and Príncipe 95
Saudi Arabia 98
Senegal 91
Serbia 93
Seychelles 98
Sierra Leone 90
Singapore 96
Slovakia 96
Solomon Islands 99
Somalia 42
South Africa 66
Spain 93
Sri Lanka 99
Sudan 95
Suriname 81
Swaziland 98
Sweden 76
Syrian Arab Republic 52
Tajikistan 96
Thailand 99
Timor-Leste 76
Togo 90
Tonga 81
Trinidad and Tobago 89
Tunisia 98
Turkey 96
Turkmenistan 99
Tuvalu 96
Uganda 85
Ukraine 52
United Arab Emirates 98
United Republic of Tanzania 97
United States of America 93
Uruguay 95
Uzbekistan 99
Vanuatu 85
Venezuela (Bolivarian Republic of) 84
Viet Nam 94
Yemen 68
Zambia 94
Zimbabwe 89

History

Preliminary work

In 1963, the American physician/geneticist Baruch Blumberg, working at the Fox Chase Cancer Center, discovered what he called the "Australia Antigen" (HBsAg) in the serum of an Australia n Aboriginal person.[57] In 1968, this protein was found to be part of the virus that causes "serum hepatitis" (hepatitis B) by virologist Alfred Prince.[58]

In 1976, Blumberg won the Nobel Prize in Physiology or Medicine for his work on hepatitis B (sharing it with Daniel Carleton Gajdusek for his work on kuru).[59] Blumberg had identified Australia antigen, the important first step, and later discovered the way to make the first hepatitis B vaccine. Blumberg's vaccine was a unique approach to the production of a vaccine; that is, obtaining the immunizing antigen directly from the blood of human carriers of the virus. In October 1969, acting on behalf of the Institute for Cancer Research, they filed an application for a patent for the production of a vaccine. This patent [USP 3,636,191] was subsequently (January 1972) granted in the United States and other countries. In 2002, Blumberg published a book, Hepatitis B: The Hunt for a Killer Virus.[60] In the book, Blumberg wrote: “It took some time before the concept was accepted by virologists and vaccine manufacturers who were more accustomed to dealing with vaccines produced by attenuation of viruses, or the use of killed viruses produced in tissue culture, or related viruses that were non-pathogenic protective (i.e., smallpox). However, by 1971, we were able to interest Merck, which had considerable experience with vaccines."

Blood-derived vaccine

During the next few years, a series of human and primate observations by scientists including Maurice Hilleman (who was responsible for vaccines at Merck), S. Krugman, R. Purcell, P. Maupas, and others provided additional support for the vaccine. In 1980, the results of the first field trial were published by W. Szmuness and his colleagues in New York City."

The American microbiologist/vaccinologist Maurice Hilleman at Merck used three treatments (pepsin, urea and formaldehyde) of blood serum together with rigorous filtration to yield a product that could be used as a safe vaccine. Hilleman hypothesized that he could make an HBV vaccine by injecting patients with hepatitis B surface protein. In theory, this would be very safe, as these excess surface proteins lacked infectious viral DNA. The immune system, recognizing the surface proteins as foreign, would manufacture specially shaped antibodies, custom-made to bind to, and destroy, these proteins. Then, in the future, if the patient were infected with HBV, the immune system could promptly deploy protective antibodies, destroying the viruses before they could do any harm.[61]

Hilleman collected blood from gay men and intravenous drug users—groups known to be at risk for viral hepatitis. This was in the late 1970s, when HIV was yet unknown to medicine. In addition to the sought-after hepatitis B surface proteins, the blood samples likely contained HIV. Hilleman devised a multistep process to purify this blood so that only the hepatitis B surface proteins remained. Every known virus was killed by this process, and Hilleman was confident that the vaccine was safe.[61]

The first large-scale trials for the blood-derived vaccine were performed on gay men, in accordance with their high-risk status. Later, Hilleman's vaccine was falsely blamed for igniting the AIDS epidemic. (See Wolf Szmuness) But, although the purified blood vaccine seemed questionable, it was determined to have indeed been free of HIV. The purification process had destroyed all viruses—including HIV.[61] The vaccine was approved in 1981.[18]

Recombinant vaccine

The blood-derived hepatitis B vaccine was withdrawn from the marketplace in 1986, replaced by Maurice Hilleman's improved recombinant hepatitis B vaccine which was approved by the FDA on 23 July 1986.[18][20][62] It was the first human vaccine produced by recombinant DNA methods.[62] For this work, scientists at Merck & Co. collaborated with William J. Rutter and colleagues at the University of California at San Francisco, as well as Benjamin Hall and colleagues at the University of Washington.[63] In 1981, William J. Rutter, Pablo DT Valenzuela and Edward Penhoet (UC Berkeley) co-founded the Chiron Corporation in Emeryville, California, which collaborated with Merck.[63][64]

The recombinant vaccine is based on Hepatitis B surface antigen (HBsAg) gene inserted into yeast (Saccharomyces cerevisiae) cells which are free of any concerns associated with human blood products.[18][65] This allows the yeast to produce only the noninfectious surface protein, without any danger of introducing actual viral DNA into the final product.[61] The vaccine contains the adjuvant amorphous aluminum hydroxyphosphate sulfate.[65]

In 2017, a two-dose HBV vaccine for adults, Heplisav-B gained U.S. Food and Drug Administration (FDA) approval.[4] It uses recombinant HB surface antigen, similar to previous vaccines, but includes a novel CpG 1018 adjuvant, a 22-mer phosphorothioate-linked oligodeoxynucleotide. It was non-inferior with respect to immunogenicity.[66]

In November 2021, Hepatitis B Vaccine (Recombinant) (Prehevbrio) was approved by the FDA.[7][67][68][69]

Immunization schedule

The US CDC ACIP first recommended the vaccine for all newborns in 1991.[70] Prior to this, the vaccine was only recommended for high-risk groups. As of the 1991 recommendation for universal newborn Hepatitis B vaccination, no other vaccines were routinely recommended for all newborns in the United States, and remains one of the very few vaccines routinely recommended for administration at birth.

Manufacture

The vaccine contains one of the viral envelope proteins, Hepatitis B surface antigen (HBsAg). It is produced by yeast cells, into which the gene for HBsAg has been inserted.[65] Afterward an immune system antibody to HBsAg is established in the bloodstream. The antibody is known as anti-HBs. This antibody and immune system memory then provide immunity to hepatitis B virus (HBV) infection.[71]

Society and culture

Legal status

On 10 December 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Heplisav B, intended for the active immunization against hepatitis B virus infection (HBV).[72] The applicant for this medicinal product is Dynavax GmbH.[72] It was approved for medical use in the European Union in February 2021.[9]

On 24 February 2022, the CHMP adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product PreHevbri, intended for the active immunization against hepatitis B virus infection (HBV).[73] The applicant for this medicinal product is VBI Vaccines B.V.[73] PreHevbri was approved for medical use in the European Union in April 2022.[10][12]

Brand names

The common brands available are Recombivax HB (Merck),[5] Engerix-B (GSK),[6] Elovac B (Human Biologicals Institute, a division of Indian Immunologicals Limited), Genevac B (Serum Institute), Shanvac B, Heplisav-B,[4][9] and Prehevbrio,[7]

Twinrix (GSK) is a vaccine against hepatitis A and hepatitis B.[74][75]

Pediarix is a vaccine against diphtheria, tetanus, pertussis, hepatitis B, and poliomyelitis.[76]

Vaxelis is a vaccine against diphtheria, tetanus, pertussis, poliomyelitis, Haemophilus influenzae type B (Meningococcal Protein Conjugate), and hepatitis B.[77][78]

Fendrix (hepatitis B (rDNA) vaccine (adjuvanted, adsorbed)) was approved for medical use in the European Union in 2005.[79]

References

  1. ↑ "Hepatitis b adult vaccine Pregnancy and Breastfeeding Warnings". 27 April 2020. https://www.drugs.com/pregnancy/hepatitis-b-adult-vaccine.html. 
  2. ↑ "Engerix B SmPC". Datapharm. 24 April 2017. https://www.medicines.org.uk/emc/product/1684/smpc. 
  3. ↑ "HBVaxPro SmPC". Datapharm. 12 March 2019. https://www.medicines.org.uk/emc/product/1684/smpc. 
  4. ↑ 4.0 4.1 4.2 "Heplisav-B". https://www.fda.gov/vaccines-blood-biologics/vaccines/heplisav-b. 
  5. ↑ 5.0 5.1 "Recombivax HB". 24 April 2019. https://www.fda.gov/vaccines-blood-biologics/vaccines/recombivax-hb. 
  6. ↑ 6.0 6.1 "Engerix-B". 3 October 2019. https://www.fda.gov/vaccines-blood-biologics/vaccines/engerix-b. 
  7. ↑ 7.0 7.1 7.2 "PreHevbrio". 13 December 2021. https://www.fda.gov/vaccines-blood-biologics/prehevbrio. 
  8. ↑ "Hepatitis B Vaccine Monograph for Professionals". 1 September 2019. https://www.drugs.com/monograph/hepatitis-b-vaccine.html. 
  9. ↑ 9.0 9.1 9.2 "Heplisav B EPAR". 9 December 2020. https://www.ema.europa.eu/en/medicines/human/EPAR/heplisav-b. 
  10. ↑ 10.0 10.1 "PreHevbri EPAR". 22 February 2022. https://www.ema.europa.eu/en/medicines/human/EPAR/prehevbri.  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  11. ↑ "Heplisav B Product information". https://ec.europa.eu/health/documents/community-register/html/h1503.htm. 
  12. ↑ 12.0 12.1 "PreHevbri Product information". https://ec.europa.eu/health/documents/community-register/html/h1641.htm. 
  13. ↑ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 13.14 13.15 13.16 13.17 13.18 "Hepatitis B vaccines: WHO position paper – July 2017". Wkly. Epidemiol. Rec. 92 (27): 369–92. July 2017. PMID 28685564. https://iris.who.int/bitstream/handle/10665/255873/WER9227-369-392.pdf?sequence=1&isAllowed=y. 
  14. ↑ 14.0 14.1 "Vaccines for preventing hepatitis B in health-care workers". The Cochrane Database of Systematic Reviews (4): CD000100. October 2005. doi:10.1002/14651858.CD000100.pub3. PMID 16235273. 
  15. ↑ A Historical Perspective on Evidence-Based Immunology. Newnes. 25 November 2015. p. 336. ISBN 9780123983756. https://books.google.com/books?id=2TMwAAAAQBAJ&pg=PA336. 
  16. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  17. ↑ World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. WHO/MHP/HPS/EML/2021.02. 
  18. ↑ 18.0 18.1 18.2 18.3 "Maurice Hilleman: Creator of Vaccines That Changed the World.". Case Studies in Public Health: 443–470. 2018. doi:10.1016/B978-0-12-804571-8.00003-2. ISBN 9780128045718. 
  19. ↑ "Maurice R. Hilleman" (in English). Lancet 365 (9472): 1682. 14 May 2005. doi:10.1016/S0140-6736(05)66536-1. PMID 15912596. 
  20. ↑ 20.0 20.1 "Chapter 8: Blood". Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases. HarperCollins. 2007. pp. 115–126, 136–140. https://vaccinemakers.org/sites/default/files/resources/HS.reading%20passage-Blood.unit2_.lesson4.FINAL_.pdf. Retrieved 9 January 2021. 
  21. ↑ Committee on Infectious Diseases; Committee On Fetus And Newborn (September 2017). "Elimination of Perinatal Hepatitis B: Providing the First Vaccine Dose Within 24 Hours of Birth". Pediatrics 140 (3): e20171870. doi:10.1542/peds.2017-1870. PMID 28847980. 
  22. ↑ "Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group". The New England Journal of Medicine 336 (26): 1855–9. June 1997. doi:10.1056/NEJM199706263362602. PMID 9197213. 
  23. ↑ "Hepatitis B vaccine". http://www.nhs.uk/Conditions/vaccinations/Pages/hepatitis-b-vaccine.aspx. 
  24. ↑ Joint Committee on Vaccination and Immunisation (2006). "Chapter 12 Immunisation of healthcare and laboratory staff—Hepatitis B". Immunisation Against Infectious Disease 2006 ("The Green Book") (3rd ed.). Edinburgh: Stationery Office. p. 468. ISBN 978-0-11-322528-6. http://www.dh.gov.uk/en/Publichealth/Healthprotection/Immunisation/Greenbook/DH_4097254?IdcService=GET_FILE&dID=115800&Rendition=Web. Retrieved 25 March 2008. 
  25. ↑ U.S. Centers for Disease Control and Prevention (CDC) (December 2011). "Use of hepatitis B vaccination for adults with diabetes mellitus: recommendations of the Advisory Committee on Immunization Practices (ACIP)". MMWR Morb. Mortal. Wkly. Rep. 60 (50): 1709–11. PMID 22189894. https://www.cdc.gov/mmwr/pdf/wk/mm6050.pdf. Retrieved 7 May 2020. 
  26. ↑ "Combined DTP–HBV–HIB vaccine versus separately administered DTP–HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB)". The Cochrane Database of Systematic Reviews 4 (4): CD005530. April 2012. doi:10.1002/14651858.CD005530.pub3. PMID 22513932. 
  27. ↑ U.S. Centers for Disease Control and Prevention (CDC) (March 2003). "FDA licensure of diphtheria and tetanus toxoids and acellular pertussis adsorbed, hepatitis B (recombinant), and poliovirus vaccine combined, (PEDIARIX) for use in infants". MMWR Morb. Mortal. Wkly. Rep. 52 (10): 203–4. PMID 12653460. 
  28. ↑ U.S. Centers for Disease Control and Prevention (CDC) (October 2008). "Licensure of a diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine and guidance for use as a booster dose". MMWR Morb. Mortal. Wkly. Rep. 57 (39): 1078–9. PMID 18830212. https://www.cdc.gov/mmwr/volumes/69/wr/pdfs/mm6905a5-H.pdf. Retrieved 7 May 2020. 
  29. ↑ "Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices". MMWR Recomm Rep 67 (1): 1–31. January 2018. doi:10.15585/mmwr.rr6701a1. PMID 29939980. PMC 5837403. https://www.cdc.gov/mmwr/volumes/67/rr/pdfs/rr6701-H.PDF. Retrieved 7 May 2020. 
  30. ↑ 30.0 30.1 "Hepatitis B immunisation for newborn infants of hepatitis B surface antigen-positive mothers". The Cochrane Database of Systematic Reviews (2): CD004790. April 2006. doi:10.1002/14651858.CD004790.pub2. PMID 16625613. 
  31. ↑ "Hepatitis B vaccination during pregnancy for preventing infant infection". The Cochrane Database of Systematic Reviews 2014 (11): CD007879. November 2014. doi:10.1002/14651858.CD007879.pub3. PMID 25385500. 
  32. ↑ "Hepatitis B immunoglobulin during pregnancy for prevention of mother-to-child transmission of hepatitis B virus". The Cochrane Database of Systematic Reviews 2017 (2): CD008545. February 2017. doi:10.1002/14651858.CD008545.pub2. PMID 28188612. 
  33. ↑ 33.0 33.1 "Ask the Experts: Hepatitis B". Immunization Action Coalition. 26 May 2022. https://www.immunize.org/askexperts/experts_hepb.asp. 
  34. ↑ 34.0 34.1 34.2 34.3 34.4 Joint Committee on Vaccination and Immunisation (2006). "Chapter 18: Hepatitis B". Immunisation Against Infectious Disease 2006 ("The Green Book") (3rd edition (Chapter 18 revised 10 October 2007) ed.). Edinburgh: Stationery Office. p. 468. ISBN 978-0-11-322528-6. http://www.dh.gov.uk/en/Publichealth/Healthprotection/Immunisation/Greenbook/DH_4097254?IdcService=GET_FILE&dID=152019&Rendition=Web. 
  35. ↑ 35.0 35.1 "Hepatitis B vaccine by intradermal route in non responder patients: an update". World J. Gastroenterol. 20 (30): 10383–94. August 2014. doi:10.3748/wjg.v20.i30.10383. PMID 25132754. 
  36. ↑ "Immunization with high-dose intradermal recombinant hepatitis B vaccine in healthcare workers who failed to respond to intramuscular vaccination". Infection Control and Hospital Epidemiology 16 (2): 88–91. February 1995. doi:10.1086/647062. PMID 7759824. 
  37. ↑ "Excellent response rate to a double dose of the combined hepatitis A and B vaccine in previous nonresponders to hepatitis B vaccine". The Journal of Infectious Diseases 198 (3): 299–304. August 2008. doi:10.1086/589722. PMID 18544037. 
  38. ↑ "Hepatitis B vaccine responsiveness in Connecticut public safety personnel". JAMA 270 (24): 2931–4. 1993. doi:10.1001/jama.270.24.2931. PMID 8254852. 
  39. ↑ "Efficacy of a high and accelerated dose of hepatitis B vaccine in alcoholic patients: a randomized clinical trial". The American Journal of Medicine 103 (3): 217–22. September 1997. doi:10.1016/S0002-9343(97)00132-0. PMID 9316554. 
  40. ↑ "Immune responses in patients with HIV infection after vaccination with recombinant Hepatitis B virus vaccine". BMC Infectious Diseases 6: 65. March 2006. doi:10.1186/1471-2334-6-65. PMID 16571140.  Cold or Flu like symptoms can develop after receiving the vaccine, but these are short lived. As with any injection, the muscle can become tender around the injection point for some time afterwards
  41. ↑ "Hepatitis B vaccine: prospects for duration of immunity". The Yale Journal of Biology and Medicine 60 (4): 333–9. 1987. PMID 3660859. 
  42. ↑ "Duration of hepatitis B immunity in low risk children receiving hepatitis B vaccinations from birth" (Free full text). The Pediatric Infectious Disease Journal 23 (7): 650–5. July 2004. doi:10.1097/01.inf.0000130952.96259.fd. PMID 15247604. http://www.medscape.com/viewarticle/483473. 
  43. ↑ "A review of the long-term protection after hepatitis A and B vaccination". Travel Medicine and Infectious Disease 5 (2): 79–84. March 2007. doi:10.1016/j.tmaid.2006.04.004. PMID 17298912. 
  44. ↑ Van Damme, Pierre (1 July 2016). "Long-term Protection After Hepatitis B Vaccine". Journal of Infectious Diseases 214 (1): 1–3. doi:10.1093/infdis/jiv750. PMID 26802140. 
  45. ↑ "Long-term immunogenicity of hepatitis B vaccination in a cohort of Italian healthy adolescents". Vaccine 25 (16): 3129–32. April 2007. doi:10.1016/j.vaccine.2007.01.045. PMID 17291637. 
  46. ↑ "Are booster immunisations needed for lifelong hepatitis B immunity? European Consensus Group on Hepatitis B Immunity". Lancet 355 (9203): 561–5. February 2000. doi:10.1016/S0140-6736(99)07239-6. PMID 10683019. 
  47. ↑ "Hepatitis B in pregnancy". World Journal of Gastroenterology 18 (34): 4677–83. September 2012. doi:10.3748/wjg.v18.i34.4677. PMID 23002336. 
  48. ↑ 48.0 48.1 "Central nervous system demyelinating diseases and recombinant hepatitis B vaccination: a critical systematic review of scientific production". Journal of Neurology 260 (8): 1951–9. August 2013. doi:10.1007/s00415-012-6716-y. PMID 23086181. 
  49. ↑ "FAQs about Hepatitis B Vaccine (Hep B) and Multiple Sclerosis". U.S. Centers for Disease Control and Prevention (CDC). 9 October 2009. https://www.cdc.gov/vaccinesafety/Vaccines/multiplesclerosis_and_hep_b.html. 
  50. ↑ "Hepatitis B vaccination and the putative risk of central demyelinating diseases - A systematic review and meta-analysis". Vaccine 36 (12): 1548–55. March 2018. doi:10.1016/j.vaccine.2018.02.036. PMID 29454521. 
  51. ↑ "Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study". Neurology 63 (5): 838–42. September 2004. doi:10.1212/01.WNL.0000138433.61870.82. PMID 15365133. 
  52. ↑ "Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines". Journal of Medical Virology 78 (2): 169–77. February 2006. doi:10.1002/jmv.20524. PMID 16372285. 
  53. ↑ "Hepatitis B vaccination and the risk of childhood-onset multiple sclerosis". Archives of Pediatrics & Adolescent Medicine 161 (12): 1176–82. December 2007. doi:10.1001/archpedi.161.12.1176. PMID 18056563. 
  54. ↑ "Autoimmune diseases after hepatitis B immunization in adults: Literature review and meta-analysis, with reference to 'autoimmune/autoinflammatory syndrome induced by adjuvants' (ASIA)". Vaccine 36 (38): 5796–5802. September 2018. doi:10.1016/j.vaccine.2018.07.074. PMID 30100071. 
  55. ↑ "Share of one-year-olds vaccinated against hepatitis B". https://ourworldindata.org/grapher/immunization-hepb3-of-one-year-old-children. 
  56. ↑ "Hepatitis B (HepB3) Immunization coverage estimates by country". http://apps.who.int/gho/data/node.main.A828?lang=en. 
  57. ↑ "A "New" Antigen In Leukemia Sera". JAMA 191 (7): 541–6. February 1965. doi:10.1001/jama.1965.03080070025007. PMID 14239025. 
  58. ↑ Howard, Colin; Zuckerman, Arie J. (1979). Hepatitis viruses of man. Boston: Academic Press. pp. 16–18. ISBN 978-0-12-782150-4. https://archive.org/details/hepatitisviruses0000zuck/page/16. 
  59. ↑ "The Nobel Prize in Physiology or Medicine 1976" (in en-US). https://www.nobelprize.org/prizes/medicine/1976/summary/. 
  60. ↑ Blumberg, Baruch (2002), Hepatitis B: The Hunt for a Killer Virus, Princeton: Princeton University Press.
  61. ↑ 61.0 61.1 61.2 61.3 "World Hepatitis Day: The History of the Hepatitis B Vaccine | Planned Parenthood Advocates of Arizona". 26 July 2012. http://blog.advocatesaz.org/2012/07/26/world-hepatitis-day-the-history-of-the-hepatitis-b-vaccine/. 
  62. ↑ 62.0 62.1 "Vaccine Development & Licensing Events" (in en). https://www.historyofvaccines.org/content/articles/vaccine-development-licensing-events. 
  63. ↑ 63.0 63.1 "THE HEPATITIS B STORY". February 2000. http://www.nasonline.org/publications/beyond-discovery/hepatitis-b-story.pdf. 
  64. ↑ "Biotechnology Spotlight Now Shines on Chiron" (in en-US). The New York Times. 13 October 1986. ISSN 0362-4331. https://www.nytimes.com/1986/10/13/business/biotechnology-spotlight-now-shines-on-chiron.html. 
  65. ↑ 65.0 65.1 65.2 "Hepatitis B Vaccine from Merck". http://www.rxlist.com/recombivax-drug.htm. 
  66. ↑ "Heplisav-B [Hepatitis B Vaccine (Recombinant), Adjuvanted label"]. https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM584762.pdf. 
  67. ↑ "ACIP Evidence to Recommendations for use of PreHevbrio Hepatitis B (HepB) Vaccine in Adults". U.S. Centers for Disease Control and Prevention (CDC). 31 March 2022. https://www.cdc.gov/vaccines/acip/recs/grade/prehevbrio-hepb-etr.html. 
  68. ↑ "Grading of Recommendations Assessment, Development and Evaluation (GRADE): PreHevbrio for Adults". U.S. Centers for Disease Control and Prevention (CDC). 31 March 2022. https://www.cdc.gov/vaccines/acip/recs/grade/prehevbrio-hepb.html. 
  69. ↑ "Advisory Committee on Immunization Practices Recommended Immunization Schedule for Adults Aged 19 Years or Older - United States, 2023". MMWR. Morbidity and Mortality Weekly Report 72 (6): 141–144. February 2023. doi:10.15585/mmwr.mm7206a2. PMID 36757861. PMC 9925137. https://www.cdc.gov/mmwr/volumes/72/wr/pdfs/mm7206a2-H.pdf. Retrieved 16 February 2023. 
  70. ↑ "Hepatitis B Virus: A Comprehensive Strategy for Eliminating Transmission in the United States Through Universal Childhood Vaccination: Recommendations of the Immunization Practices Advisory Committee". MMWR 40 (RR-13): 1–19. 22 November 1991. PMID 1835756. https://www.cdc.gov/mmwr/preview/mmwrhtml/00033405.htm. Retrieved 15 May 2023. 
  71. ↑ "CDC Viral Hepatitis". U.S. Centers for Disease Control and Prevention (CDC). 24 July 2009. https://www.cdc.gov/hepatitis/index.htm. 
  72. ↑ 72.0 72.1 "Heplisav B: Pending EC decision". 10 December 2020. https://www.ema.europa.eu/en/medicines/human/summaries-opinion/heplisav-b.  Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  73. ↑ 73.0 73.1 "PreHevbri: Pending EC decision". 25 February 2022. https://www.ema.europa.eu/en/medicines/human/summaries-opinion/prehevbri.  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  74. ↑ "Hepatitis A & hepatitis B recombinant vaccine - Drug Summary". Prescriber's Digital Reference. https://www.pdr.net/drug-summary/Twinrix-hepatitis-A--amp--hepatitis-B--recombinant--vaccine-231. 
  75. ↑ "Twinrix". https://www.fda.gov/vaccines-blood-biologics/vaccines/twinrix. 
  76. ↑ "Pediarix". https://www.fda.gov/vaccines-blood-biologics/vaccines/pediarix. 
  77. ↑ "Vaxelis EPAR". 19 February 2019. https://www.ema.europa.eu/en/medicines/human/EPAR/vaxelis. 
  78. ↑ "Vaxelis". https://www.fda.gov/vaccines-blood-biologics/vaxelis. 
  79. ↑ "Fendrix EPAR". 2 February 2005. https://www.ema.europa.eu/en/medicines/human/EPAR/fendrix. 

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