Chemistry:Erastin
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Revision as of 19:06, 30 December 2021 by imported>Steve Marsio (url)
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| Formula | C30H31ClN4O4 |
| Molar mass | 547.05 g/mol g·mol−1 |
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Erastin is a small molecule capable of initiating ferroptotic cell death.[1] Erastin binds and inhibits VDAC2 and VDAC3[2] and functionally inhibits the cystine-glutamate antiporter System Xc-.[3] Cells treated with erastin are deprived of cysteine and are unable to synthesize the antioxidant glutathione. Depletion of glutathione eventually leads to excessive lipid peroxidation and cell death.
References
- ↑ Dixon, SJ; Lemberg, KM; Lamprecht, MR; Skouta, R; Zaitsev, EM; Gleason, CE; Patel, DN; Bauer, AJ et al. (25 May 2012). "Ferroptosis: an iron-dependent form of nonapoptotic cell death.". Cell 149 (5): 1060–72. PMID 22632970.
- ↑ Yagoda, N; von Rechenberg, M; Zaganjor, E; Bauer, AJ; Yang, WS; Fridman, DJ; Wolpaw, AJ; Smukste, I et al. (14 June 2007). "RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.". Nature 447 (7146): 864–8. PMID 17568748.
- ↑ Dixon, SJ; Patel, DN; Welsch, M; Skouta, R; Lee, ED; Hayano, M; Thomas, AG; Gleason, CE et al. (20 May 2014). "Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.". eLife 3: e02523. PMID 24844246.
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