Biology:CALHM1
 Generic protein structure example |
Calcium homeostasis modulator 1 (CALHM1) is a pore-forming subunit of a voltage-gated ion channel and a voltage-gated ATP channel that in humans is encoded by the CALHM1 gene.[1][2]
Function
Central nervous system
CALHM1 was identified by a tissue-specific gene expression profiling approach[3] that screened for genes located on susceptibility loci for late-onset Alzheimer's disease (AD) and that are preferentially expressed in the hippocampus,[1] a brain region affected early in AD. CALHM1 is a plasma membrane calcium-permeable ion channel regulated by voltage and extracellular calcium levels.[4] The exact function of CALHM1 in the brain is not completely understood, but studies have shown that CALHM1 controls neuronal intracellular calcium homeostasis and signaling, as well as calcium-dependent neuronal excitability and memory in mouse models.[4][5][6] Recent data have also shown that CALHM1 might facilitate the proteolytic degradation of the cerebral amyloid beta peptide, a culprit in AD pathogenesis.[7]
Peripheral taste system
CALHM1 is expressed in taste bud cells where it controls purinergic receptor-mediated taste transduction in the gustatory system.[8][9]
See also
References
- ↑ 1.0 1.1 "A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk". Cell 133 (7): 1149–61. Jun 2008. doi:10.1016/j.cell.2008.05.048. PMID 18585350.
- ↑ "How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel". BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 35 (12): 1111–8. December 2013. doi:10.1002/bies.201300077. PMID 24105910.
- ↑ "TissueInfo: high-throughput identification of tissue expression profiles and specificity". Nucleic Acids Research 29 (21): E102-2. Nov 2001. doi:10.1093/nar/29.21.e102. PMID 11691939.
- ↑ 4.0 4.1 "Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability". Proceedings of the National Academy of Sciences of the United States of America 109 (28): E1963-71. Jul 2012. doi:10.1073/pnas.1204023109. PMID 22711817. Bibcode: 2012PNAS..109E1963M.
- ↑ "CALHM1 controls the Ca²⁺-dependent MEK, ERK, RSK and MSK signaling cascade in neurons". J Cell Sci 126 (Pt 5): 1199–206. Mar 2013. doi:10.1242/jcs.117135. PMID 23345406.
- ↑ "CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice". Sci Rep 6 (24250): 24250. Apr 2016. doi:10.1038/srep24250. PMID 27066908. Bibcode: 2016NatSR...624250V.
- ↑ "CALHM1 ion channel elicits amyloid-β clearance by insulin-degrading enzyme in cell lines and in vivo in the mouse brain". J Cell Sci 128 (13): 2330–8. May 2015. doi:10.1242/jcs.167270. PMID 25999473.
- ↑ "CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes". Nature 495 (7440): 223–6. Mar 2013. doi:10.1038/nature11906. PMID 23467090. Bibcode: 2013Natur.495..223T.
- ↑ "A taste for ATP: neurotransmission in taste buds". Front Cell Neurosci 7: 264. Dec 2013. doi:10.3389/fncel.2013.00264. PMID 24385952.
External links
- Human CALHM1 genome location and CALHM1 gene details page in the UCSC Genome Browser.
Further reading
- "Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations". PLOS ONE 4 (12): e7682. Dec 2009. doi:10.1371/journal.pone.0007682. PMID 19997627. Bibcode: 2009PLoSO...4.7682M.
- "Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1". Biochemical and Biophysical Research Communications 391 (1): 722–6. Jan 2010. doi:10.1016/j.bbrc.2009.11.127. PMID 19944073.
- "Optimism and health-relevant cognitions after a myocardial infarction". Psychological Reports 67 (3 Pt 2): 1131–1135. Dec 1990. doi:10.2466/pr0.1990.67.3f.1131. PMID 2084739.
- "A polymorphism in CALHM1 is associated with temporal lobe epilepsy". Epilepsy & Behavior 20 (4): 681–5. Apr 2011. doi:10.1016/j.yebeh.2011.02.007. PMID 21439911.
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