Biology:GntR-DTE RNA motif
| gntR-DTE | |
|---|---|
 Consensus secondary structure and sequence conservation of gntR-DTE RNA | |
| Identifiers | |
| Symbol | gntR-DTE |
| Rfam | RF02989 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
The gntR-DTE RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] gntR-DTE motifs are found in some, but not all species within the genus Streptomyces.
It is ambiguous whether gntR-DTE RNAs function as cis-regulatory elements or whether they operate in trans as small RNAs. Of the 7 known examples of gntR RNAs, 6 are upstream of protein-coding genes, suggesting a cis-regulatory function. However, having more than 10% of the RNAs no upstream of a protein-coding gene would be unusually high for a cis-regulatory RNA. Additionally, the reverse-complement of the RNA would be consistently upstream of protein-coding genes, of which most encode helix-turn-helix proteins of the XRE-like family. However, there is no other evidence to suggest that the RNA is transcribed from the opposite strand.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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