Biography:Gerard Evan

From HandWiki
Short description: British biologist
Gerard Evan
Born (1955-08-17) 17 August 1955 (age 68)[1]
Alma materSt Peter's College, Oxford
King's College, Cambridge[1]
Known forDisease Models & Mechanisms
AwardsFellow of the Royal Society (2004)
FMedSci (1999)[2]
PhD (1982)
Scientific career
FieldsCancer[3][4][5][6][7][8]
Disease biology
Myc regulator gene[9]
p53 tumour suppressor[10]
InstitutionsUniversity of Oxford
University of Cambridge
UCSF[1][11]
Cancer Research UK[12]
Ensemble Therapeutics
ThesisMonoclonal antibodies as reagents for the analysis of cell surfaces (1982)
Websitewww.bioc.cam.ac.uk/uto/evan
labmed.ucsf.edu/about/faculty/pathology-gevan.html

Gerard Ian Evan FRS, FMedSci (born 17 August 1955) is a British biologist and, since May 2022, Professor of Cancer Biology at King's College London and a principal group leader in the Francis Crick Institute. Prior to this he was Sir William Dunn Professor and Head of Biochemistry at the University of Cambridge (2009-2022).[11][13]

Education

Evan was educated at St Peter's College, Oxford, where he studied Biochemistry, and King's College, Cambridge, where he was awarded his PhD in 1982 for research using Monoclonal antibodies.[1][14]

Research

Evan does research to the determine the molecular basis of cancer.[15][16][17][18][19][20][21][22]

Career

Prior to Cambridge, Evan was Royal Society Napier Professor at University College London and the Imperial Cancer Research Fund (1988-99), then Gerson & Barbara Bass Bakar Distinguished Professor of Cancer Biology, at University of California, San Francisco (1999-2011).

References

  1. ↑ 1.0 1.1 1.2 1.3 "EVAN, Prof. Gerard Ian". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press. http://www.ukwhoswho.com/view/article/oupww/whoswho/U45197. (Subscription content?)
  2. ↑ http://www.acmedsci.ac.uk/p59fid5303.html [|permanent dead link|dead link}}]
  3. ↑ Finch, A. J.; Soucek, L.; Junttila, M. R.; Swigart, L. B.; Evan, G. I. (2009). "Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/ -Catenin Pathway Activation". Molecular and Cellular Biology 29 (19): 5306–5315. doi:10.1128/MCB.01745-08. PMID 19635809. 
  4. ↑ Garcia, D.; Warr, M. R.; Martins, C. P.; Brown Swigart, L.; Passegue, E.; Evan, G. I. (2011). "Validation of MdmX as a therapeutic target for reactivating p53 in tumors". Genes & Development 25 (16): 1746–1757. doi:10.1101/gad.16722111. PMID 21852537. 
  5. ↑ Murphy, D. J.; Junttila, M. R.; Pouyet, L.; Karnezis, A.; Shchors, K.; Bui, D. A.; Brown-Swigart, L.; Johnson, L. et al. (2008). "Distinct Thresholds Govern Myc's Biological Output in Vivo". Cancer Cell 14 (6): 447–457. doi:10.1016/j.ccr.2008.10.018. PMID 19061836. 
  6. ↑ Sodir, N. M.; Swigart, L. B.; Karnezis, A. N.; Hanahan, D.; Evan, G. I.; Soucek, L. (2011). "Endogenous Myc maintains the tumor microenvironment". Genes & Development 25 (9): 907–916. doi:10.1101/gad.2038411. PMID 21478273. 
  7. ↑ Kain, K. (2008). "The future of cancer therapy: An interview with Gerard Evan". Disease Models and Mechanisms 1 (2–3): 90–93. doi:10.1242/dmm.001396. PMID 19048069. 
  8. ↑ Anon (2008). "Making the paper: Gerard Evan". Nature 455 (7213): xiii. doi:10.1038/7213xiiia. 
  9. ↑ Evan, G. (2012). "Taking a Back Door to Target Myc". Science 335 (6066): 293–294. doi:10.1126/science.1217819. PMID 22267799. Bibcode: 2012Sci...335..293E. 
  10. ↑ Junttila, Melissa R.; Evan, Gerard I. (2009). "P53 — a Jack of all trades but master of none". Nature Reviews Cancer 9 (11): 821–829. doi:10.1038/nrc2728. PMID 19776747. 
  11. ↑ 11.0 11.1 "UCSF Departments of Pathology and Laboratory Medicine | About | Faculty | Gerard I. Evan, PhD, FRS, FMedSci". http://labmed.ucsf.edu/about/faculty/pathology-gevan.html. 
  12. ↑ "Gerard Evan : Cancer Research UK". http://www.cancerresearchuk.org/science/research/who-and-what-we-fund/browse-by-location/cambridge/university-of-cambridge/gerard-evan-4750. 
  13. ↑ List of publications from Microsoft Academic
  14. ↑ Evan, Gerard (1982). Monoclonal antibodies as reagents for the analysis of cell surfaces (PhD thesis). University of Cambridge. Cite has empty unknown parameter: |1= (help)
  15. ↑ Christophorou, M. A.; Ringshausen, I.; Finch, A. J.; Swigart, L. B.; Evan, G. I. (2006). "The pathological response to DNA damage does not contribute to p53-mediated tumour suppression". Nature 443 (7108): 214–217. doi:10.1038/nature05077. PMID 16957739. Bibcode: 2006Natur.443..214C. 
  16. ↑ Junttila, M. R.; Karnezis, A. N.; Garcia, D.; Madriles, F.; Kortlever, R. M.; Rostker, F.; Brown Swigart, L.; Pham, D. M. et al. (2010). "Selective activation of p53-mediated tumour suppression in high-grade tumours". Nature 468 (7323): 567–571. doi:10.1038/nature09526. PMID 21107427. Bibcode: 2010Natur.468..567J. 
  17. ↑ "Modelling Myc inhibition as a cancer therapy". Nature 455 (7213): 679–683. 2008. doi:10.1038/nature07260. PMID 18716624. Bibcode: 2008Natur.455..679S. 
  18. ↑ Evan, Gerard I.; Vousden, Karen H. (2001). "Proliferation, cell cycle and apoptosis in cancer". Nature 411 (6835): 342–348. doi:10.1038/35077213. PMID 11357141. Bibcode: 2001Natur.411..342E. 
  19. ↑ Hueber, A. O.; Zörnig, M.; Lyon, D.; Suda, T.; Nagata, S.; Evan, G. I. (1997). "Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis". Science 278 (5341): 1305–1309. doi:10.1126/science.278.5341.1305. PMID 9360929. Bibcode: 1997Sci...278.1305H. 
  20. ↑ Chittenden, T.; Harrington, E. A.; O'Connor, R.; Remington, C.; Lutz, R. J.; Evan, G. I.; Guild, B. C. (1995). "Induction of apoptosis by the Bcl-2 homologue Bak". Nature 374 (6524): 733–736. doi:10.1038/374733a0. PMID 7715730. Bibcode: 1995Natur.374..733C. 
  21. ↑ Fanidi, A.; Harrington, E. A.; Evan, G. I. (1992). "Cooperative interaction between c-myc and bcl-2 proto-oncogenes". Nature 359 (6395): 554–556. doi:10.1038/359554a0. PMID 1406976. Bibcode: 1992Natur.359..554F. 
  22. ↑ Amati, B.; Dalton, S.; Brooks, M. W.; Littlewood, T. D.; Evan, G. I.; Land, H. (1992). "Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max". Nature 359 (6394): 423–426. doi:10.1038/359423a0. PMID 1406955. Bibcode: 1992Natur.359..423A. 

External links

Academic offices
Preceded by
[[]] 		Professor of Cancer Biology at the King's College London
2020–present 		Incumbent



Retrieved from "https://handwiki.org/wiki/index.php?title=Biography:Gerard_Evan&oldid=2103480"