Biography:Kenneth H. Wolfe
Ken Wolfe | |
---|---|
![]() Ken Wolfe at the Royal Society admissions day in London, July 2017 | |
Born | Kenneth Henry Wolfe |
Alma mater | University of Dublin (BA, PhD) |
Awards | EMBO Member (2010)[1] |
Scientific career | |
Fields | Comparative genomics Yeast genetics Bioinformatics[2] |
Institutions | University College Dublin Trinity College, Dublin Indiana University Bloomington[3] |
Thesis | Rates of nucleotide substitution in higher plants and mammals (1990) |
Doctoral advisor | Paul M. Sharp[4][5][6] |
Other academic advisors | Jeffrey D. Palmer[7] |
Doctoral students | |
Website | wolfe |
Kenneth Henry Wolfe FRS MRIA[11][12] is Professor of Genomic Evolution at University College Dublin (UCD), Ireland.[13][11][14]
Education
Wolfe was educated at Trinity College, Dublin where he was awarded Bachelor of Arts degree in Genetics in 1986[3] followed by a PhD in 1990[6] for research investigating synonymous substitution in vascular plants and mammals supervised by Paul M. Sharp.[4][5][6][15]
Research and career
Wolfe's research focuses on comparative genomics, yeast genetics and bioinformatics.[2][16][17] Work in his laboratory investigates the evolution of eukaryotic genomes and chromosome organisation.[12] He is best known for his discovery that the genome of the yeast Saccharomyces cerevisiae underwent complete genome duplication about 100 million years ago,[18] an event that is now known to be the result of hybridization between two divergent species.[12] This finding reshaped our understanding both of yeast biology, and of mechanisms of genome evolution in eukaryotes.[12] His subsequent discoveries of similar ancient genome duplications (paleopolyploidy)[19] during human evolution, and in almost all families of flowering plants, led to the realisation that whole-genome duplication is widespread.[12] His group also studies the origin and evolution of mating systems in yeasts, and the process of mating-type switching in which one cell type can change into another by moving or replacing a section of chromosome.[12]
Wolfe was a postdoctoral researcher with Jeffrey D. Palmer[7] at Indiana University Bloomington before returning to Ireland in 1992 to establish his research group in the Genetics Department of Trinity College Dublin,[20][3] where he has remained for over 20 years. (As of 2017) his most highly cited peer reviewed papers[2][14][16] have been published in leading scientific journals including Nature,[18][21] PNAS,[22] The Plant Cell,[19][23] Genome Research[24] and Nature Reviews Genetics.[7]
Former doctoral students from the Wolfe lab include Mario A. Fares,[4] Aoife McLysaght,[4][8][9] Estelle Proux-Wéra[4] and Cathal Seoighe.[5][10]
Awards and honours
Wolfe was elected a Fellow of the Royal Society (FRS) in 2017,[12] a member of the Royal Irish Academy (MRIA) in 2000[11] and a member of the European Molecular Biology Organization (EMBO) in 2010.[1] In 2011 he served as president of the Society for Molecular Biology and Evolution (smbe.org).[25]
References
- ↑ 1.0 1.1 Anon (2010). "EMBO member: Kenneth H. Wolfe". Heidelberg: European Molecular Biology Organization. Archived from the original on 2017-01-31. https://web.archive.org/web/20170131223758/http://people.embo.org/profile/kenneth-h-wolfe.
- ↑ 2.0 2.1 2.2 {{Google Scholar id}} template missing ID and not present in Wikidata.
- ↑ 3.0 3.1 3.2 Ken Wolfe's Entry at ORCID
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Anon (2017). "Kenneth H. Wolfe academic geneaology". Archived from the original on 2017-07-11. https://web.archive.org/web/20170711135424/https://academictree.org/compbio/tree.php?pid=64740.
- ↑ 5.0 5.1 5.2 5.3 Kenneth H. Wolfe at the Mathematics Genealogy Project
- ↑ 6.0 6.1 6.2 Wolfe, Kenneth H. (1990). Rates of nucleotide substitution in higher plants and mammals (PhD thesis). Trinity College, Dublin. OCLC 842511087. Copac 11666046.
- ↑ 7.0 7.1 7.2 Wolfe, Kenneth H. (2001). "Yesterday's polyploids and the mystery of diploidization". Nature Reviews Genetics 2 (5): 333–341. doi:10.1038/35072009. ISSN 1471-0056. PMID 11331899. (Subscription content?)
- ↑ 8.0 8.1 McLysaght, Aoife (2002). Evolution of vertebrate genome organisation (PDF) (PhD thesis). Trinity College, Dublin. OCLC 842498402. Copac 11660313. Archived from the original (PDF) on 2017-11-06.
- ↑ 9.0 9.1 Wolfe, Ken (2017). "Wolfe lab alumni". Archived from the original on 2017-07-11. https://web.archive.org/web/20170711122103/http://wolfe.ucd.ie/lab/yore.php.
- ↑ 10.0 10.1 Seoighe, Cathal (2000). Gene order evolution and genomic analysis of the model eukaryote, Saccharomyces cerevisiae, and other yeast species (PhD thesis). Trinity College, Dublin. OCLC 842501444. Copac 11661350.
- ↑ 11.0 11.1 11.2 Anon (2000). "Kenneth H. Wolfe FTCD". Dublin: Royal Irish Academy. https://www.ria.ie/kenneth-h-wolfe. [|permanent dead link|dead link}}]
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Anon (2017). "Professor Kenneth Wolfe FRS". London: Royal Society. Archived from the original on 2017-05-05. https://web.archive.org/web/20170505140928/https://royalsociety.org/people/kenneth-wolfe-13436/. One or more of the preceding sentences incorporates text from the royalsociety.org website where: “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Royal Society Terms, conditions and policies". Archived from the original on 2016-11-11. https://web.archive.org/web/20161111170346/https://royalsociety.org/about-us/terms-conditions-policies/. Retrieved 2016-03-09.
- ↑ UCD Professor Kenneth Wolfe elected Fellow of the Royal Society on YouTube, University College Dublin
- ↑ 14.0 14.1 Kenneth H. Wolfe publications from Europe PubMed Central
- ↑ Sharp, Paul M.; Cowe, Elizabeth; Higgins, Desmond G.; Shields, Denis C.; Wolfe, Kenneth H.; Wright, Frank (1988). "Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity". Nucleic Acids Research 16 (17): 8207–8211. doi:10.1093/nar/16.17.8207. ISSN 0305-1048. PMID 3138659.
- ↑ 16.0 16.1 Kenneth H. Wolfe publications indexed by the Scopus bibliographic database. (Subscription content?)
- ↑ Sherlock, Gavin; Schröder, Markus S.; Martinez de San Vicente, Kontxi; Prandini, Tâmara H. R.; Hammel, Stephen; Higgins, Desmond G.; Bagagli, Eduardo; Wolfe, Kenneth H. et al. (2016). "Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species". PLOS Genetics 12 (11): e1006404. doi:10.1371/journal.pgen.1006404. ISSN 1553-7404. PMID 27806045.
- ↑ 18.0 18.1 Wolfe, Kenneth H.; Shields, Denis C. (1997). "Molecular evidence for an ancient duplication of the entire yeast genome". Nature 387 (6634): 708–713. doi:10.1038/42711. ISSN 0028-0836. PMID 9192896. (Subscription content?)
- ↑ 19.0 19.1 Blanc, Guillaume; Wolfe, Kenneth H. (2004). "Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes". The Plant Cell 16 (7): 1667–1678. doi:10.1105/tpc.021345. ISSN 1040-4651. PMID 15208399.
- ↑ "Trinity College Dublin Genetics Department". http://www.tcd.ie/Genetics.
- ↑ Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K. (2001). "Initial sequencing and analysis of the human genome". Nature 409 (6822): 860–921. doi:10.1038/35057062. ISSN 0028-0836. PMID 11237011. Bibcode: 2001Natur.409..860L. https://deepblue.lib.umich.edu/bitstream/2027.42/62798/1/409860a0.pdf.
- ↑ Wolfe, K. H.; Li, W. H.; Sharp, P. M. (1987). "Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs.". Proceedings of the National Academy of Sciences 84 (24): 9054–9058. doi:10.1073/pnas.84.24.9054. ISSN 0027-8424. PMID 3480529.
- ↑ Blanc, Guillaume; Wolfe, Kenneth H. (2004). "Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution". The Plant Cell 16 (7): 1679–1691. doi:10.1105/tpc.021410. ISSN 1040-4651. PMID 15208398.
- ↑ Blanc, G.; Hokamp, Karsten; Wolfe, Kenneth H. (2003). "A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome". Genome Research 13 (2): 137–144. doi:10.1101/gr.751803. ISSN 1088-9051. PMID 12566392.
- ↑ Anon (2017). "SMBE Council members". http://www.smbe.org/smbe/ABOUT/Council.aspx/.