Biography:Mihai Ioan Botez
Mihai Ioan Botez (29 June 1927 – 2 June 1998) was born in Ploiești, Romania, trained at Carol Davila University of Medicine and Pharmacy, a neurologist and academic who specialized in the field of neuropsychology. He immigrated to Montreal in the 1970s, becoming a professor at the Université de Montréal and director of the department of Neurology at the hospital Hôtel-Dieu de Montréal.
Academic life
Botez trained at the Romanian School of Neurology founded by Gheorghe Marinescu. He immigrated to Canada in the 1970s, where he became professor of neurology at the Université de Montréal and head of the Neurology Service at the hospital Hôtel-Dieu de Montréal.[1][2] From 1985, his main work featured the role of the cerebellum on human behavior.[3]
Behavioral neurology
Botez became a proficient researcher in several fields of behavioral neurology in both human and animal subjects.[4]
Folic acid
In the 1970s, Botez' main research subject was the effects of folic acid and thiamine on the central nervous system, relevant for restless legs syndrome, epilepsy, polyneuropathy, and chronic fatigue syndrome.[5][6][7] These articles demonstrated the use of B vitamins in the treatment of neurologic symptoms.
Cerebellum
In the 1980s, Botez pioneered studies on the effects of lesions to the cerebellum on cognition, including patients with spinocerebellar ataxia, Friedreich's ataxia, and mice with spontaneous mutations causing cerebellar damage, such as GRID2-Lc Lurcher.[8][9][10][11][12][13][14] These articles demonstrated the role of the cerebellum in neuropsychology.
Neurochemistry
Together with neurochemists Simon N Young of the Allan Memorial Institute and Tomas A Reader of the Université de Montréal, Botez obtained measures of brain concentrations of neurotransmitters such as biogenic amine metabolites of dopamine, norepinephrine, and serotonin in patients, as well as concentrations and receptor density of these neurotransmitters and glutamic acid in mouse brain, he and his co-workers in neurochemistry provided vital cues to underlying neurochemical abnormalities in patients with B vitamin anomalies and patients with cerebellar atrophy.[15][16][17][18] Such studies lead to successful trials with amantadine, a substance facilitating dopamine transmission, to ameliorate reaction times in cerebellar atrophy,[19] as well as respiratory failure.[20]
References
- ↑ Léveillé, Jean. "Hommage posthume au Dr. Mihai-Ioan Botez". L'Association des médecins de langue française du Canada. http://www.amlfc.org/Articles/1998_11_03.html.
- ↑ Forum, Université de Montréal, 1987, vol 21, no 28, p 1.
- ↑ Forum, Université de Montréal, 1989, vol 24, no 10, p 5.
- ↑ MI Botez (éd) Neuropsychologie clinique et neurologie du comportement. Paris: Presses de l’Université de Montréal et Masson, 2e éd., pp 319-337, 1996.
- ↑ "Polyneuropathy and folate deficiency". Archives of Neurology 35 (9): 581–4. September 1978. doi:10.1001/archneur.1978.00500330029005. PMID 210747. http://archneur.ama-assn.org/cgi/pmidlookup?view=long&pmid=210747.[yes|permanent dead link|dead link}}]
- ↑ "Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association". Applied Neurophysiology 42 (3): 171–83. 1979. doi:10.1159/000102361. PMID 464598.
- ↑ "Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies". European Neurology 16 (1–6): 230–46. 1977. doi:10.1159/000114904. PMID 615714.
- ↑ "Radiologic correlates of reaction time measurements in olivopontocerebellar atrophy". European Neurology 33 (4): 304–9. 1993. doi:10.1159/000116959. PMID 8348918.
- ↑ "Olivopontocerebellar atrophy and Friedreich's ataxia: neuropsychological consequences of bilateral versus unilateral cerebellar lesions". International Review of Neurobiology 41: 387–410. 1997. doi:10.1016/S0074-7742(08)60361-X. PMID 9378599.
- ↑ Botez MI (1993). "Cerebellum and non-motor behaviour". Romanian Journal of Neurology and Psychiatry 31 (3–4): 189–93. PMID 8011482.
- ↑ "Cognitive behavior in heredodegenerative ataxias". European Neurology 33 (5): 351–7. 1993. doi:10.1159/000116970. PMID 8243509.
- ↑ "The cerebellum and learning processes in animals". Brain Research. Brain Research Reviews 15 (3): 325–32. 1990. doi:10.1016/0165-0173(90)90006-A. PMID 2289089.
- ↑ "Role of the cerebellum in complex human behavior". Italian Journal of Neurological Sciences 10 (3): 291–300. June 1989. doi:10.1007/BF02333774. PMID 2767936.
- ↑ "Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought". Neurology 35 (8): 1152–7. August 1985. doi:10.1212/wnl.35.8.1152. PMID 4022349.
- ↑ "Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias". The Canadian Journal of Neurological Sciences 28 (2): 134–40. May 2001. PMID 11383938. http://cjns.metapress.com/openurl.asp?genre=article&issn=0317-1671&volume=28&issue=2&spage=134. Retrieved 2010-04-10.
- ↑ "Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid". Brain 114 (1A): 333–48. February 1991. PMID 1705463.
- ↑ "Brain dopamine and amino acid concentrations in Lurcher mutant mice". Brain Research Bulletin 45 (5): 489–93. March 1998. doi:10.1016/S0361-9230(97)00430-9. PMID 9570718.
- ↑ "Regional distribution of the 5-HT innervation in the brain of normal and lurcher mice as revealed by [3H]citalopram quantitative autoradiography". Journal of Chemical Neuroanatomy 10 (2): 157–71. April 1996. doi:10.1016/0891-0618(96)00115-9. PMID 8783044.
- ↑ "Amantadine hydrochloride treatment in olivopontocerebellar atrophy: a long-term follow-up study". European Neurology 41 (4): 212–5. 1999. doi:10.1159/000008053. PMID 10343152.
- ↑ "Can we treat respiratory failure in Friedreich ataxia?". Archives of Neurology 54 (8): 1030–3. August 1997. doi:10.1001/archneur.1997.00550200086015. PMID 9267979. http://archneur.ama-assn.org/cgi/pmidlookup?view=long&pmid=9267979.[yes|permanent dead link|dead link}}]
 |  |
