Biology:1-hydroxy-2-naphthoate 1,2-dioxygenase
| 1-hydroxy-2-naphthoate 1,2-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.11.38 | ||||||||
| CAS number | 85941-64-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 1-hydroxy-2-naphthoate 1,2-dioxygenase (EC 1.13.11.38) is an enzyme that catalyzes the chemical reaction
- 1-hydroxy-2-naphthoate + O2 [math]\displaystyle{ \rightleftharpoons }[/math] (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate
Thus, the two substrates of this enzyme are 1-hydroxy-2-naphthoate and O2, whereas its product is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate.
This enzyme participates in naphthalene and anthracene degradation. It employs one cofactor, iron.
Nomenclature
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 1-hydroxy-2-naphthoate dioxygenase, 1-hydroxy-2-naphthoate-degrading enzyme, and 1-hydroxy-2-naphthoic acid dioxygenase.
References
- "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". Journal of Bacteriology 154 (1): 113–7. April 1983. PMID 6833175.
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