Biology:2-Polyprenyl-6-hydroxyphenyl methylase

From HandWiki
2-polyprenyl-6-hydroxyphenyl methylase
Identifiers
EC number2.1.1.222
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

2-polyprenyl-6-hydroxyphenyl methylase (EC 2.1.1.222, ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenyl methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol

UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.

References

  1. "Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis". The Journal of Biological Chemistry 274 (31): 21665–72. July 1999. doi:10.1074/jbc.274.31.21665. PMID 10419476. 
  2. "Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis". Biochemistry 35 (30): 9797–806. July 1996. doi:10.1021/bi9602932. PMID 8703953. 

External links