Biology:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
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Short description: Class of enzymes
| OHCU decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | OHCU_decarbox | ||||||||
| Pfam | PF09349 | ||||||||
| InterPro | IPR018020 | ||||||||
| |||||||||
In molecular biology 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) EC 4.1.1.n1 is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into S(+)-allantoin.[1][2] It is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.[3][4]
References
- ↑ "Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes". Nat. Chem. Biol. 2 (3): 144–8. March 2006. doi:10.1038/nchembio768. PMID 16462750.
- ↑ "The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.". J Biol Chem 282 (25): 18182–9. 2007. doi:10.1074/jbc.M701297200. PMID 17428786.
- ↑ "Structural and functional basis for (S)-allantoin formation in the ureide pathway.". J Biol Chem 282 (32): 23457–64. 2007. doi:10.1074/jbc.M703211200. PMID 17567580.
- ↑ "Update on ureide degradation in legumes.". J Exp Bot 57 (1): 5–12. 2006. doi:10.1093/jxb/erj013. PMID 16317038.
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