Biology:23S rRNA (adenine2503-C8)-methyltransferase
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Short description: Class of enzymes
| 23S rRNA (adenine2503-C8)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.224 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (adenine2503-C8)-methyltransferase (EC 2.1.1.224, Cfr (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C8)-methyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA
This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
References
- ↑ "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA 15 (2): 327–36. February 2009. doi:10.1261/rna.1371409. PMID 19144912.
- ↑ "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Research 38 (5): 1652–63. March 2010. doi:10.1093/nar/gkp1142. PMID 20007606.
- ↑ "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society 132 (11): 3953–64. March 2010. doi:10.1021/ja910850y. PMID 20184321.
- ↑ "RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift". Proceedings of the National Academy of Sciences of the United States of America 108 (10): 3930–4. March 2011. doi:10.1073/pnas.1017781108. PMID 21368151. Bibcode: 2011PNAS..108.3930Y.
- ↑ "A radically different mechanism for S-adenosylmethionine-dependent methyltransferases". Science 332 (6029): 604–7. April 2011. doi:10.1126/science.1200877. PMID 21415317. Bibcode: 2011Sci...332..604G.
- ↑ "Structural basis for methyl transfer by a radical SAM enzyme". Science 332 (6033): 1089–92. May 2011. doi:10.1126/science.1205358. PMID 21527678. Bibcode: 2011Sci...332.1089B.
External links
- 23S+rRNA+(adenine2503-C8)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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