Biology:23S rRNA (guanine1835-N2)-methyltransferase

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Short description: Class of enzymes
23S rRNA (guanine1835-N2)-methyltransferase
Identifiers
EC number2.1.1.174
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

23S rRNA (guanine1835-N2)-methyltransferase (EC 2.1.1.174, ygjO (gene), rlmG (gene), ribosomal RNA large subunit methyltransferase G) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine1835-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine1835 in 23S rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N2-methylguanine1835 in 23S rRNA

The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.

References

  1. "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA". Journal of Molecular Biology 364 (1): 26–31. November 2006. doi:10.1016/j.jmb.2006.09.008. PMID 17010380. 

External links