Biology:23S rRNA (guanine748-N1)-methyltransferase
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Short description: Class of enzymes
| 23S rRNA (guanine748-N1)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.188 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
23S rRNA (guanine748-N1)-methyltransferase (EC 2.1.1.188, Rlma(II), Rlma2, 23S rRNA m1G748 methyltransferase, RlmaII, Rlma II, tylosin-resistance methyltransferase RlmA(II), TlrB, rRNA large subunit methyltransferase II) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine748-N1)-methyltransferase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanine748 in 23S rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA
The enzyme specifically methylates guanine748 at N1 in 23S rRNA.
References
- ↑ "The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748". Journal of Molecular Biology 337 (5): 1073–7. April 2004. doi:10.1016/j.jmb.2004.02.030. PMID 15046978.
- ↑ "The tylosin resistance gene tlrB of Streptomyces fradiae encodes a methyltransferase that targets G748 in 23S rRNA". Molecular Microbiology 37 (4): 811–20. August 2000. doi:10.1046/j.1365-2958.2000.02046.x. PMID 10972803.
- ↑ "Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII". The EMBO Journal 22 (2): 183–92. January 2003. doi:10.1093/emboj/cdg022. PMID 12514124.
- ↑ "Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II)". Journal of Molecular Biology 372 (2): 525–34. September 2007. doi:10.1016/j.jmb.2007.06.068. PMID 17673230.
- ↑ "Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I". Journal of Molecular Biology 378 (5): 969–75. May 2008. doi:10.1016/j.jmb.2008.03.024. PMID 18406425.
- ↑ "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria". Molecular Microbiology 44 (1): 195–204. April 2002. doi:10.1046/j.1365-2958.2002.02866.x. PMID 11967079.
External links
- 23S+rRNA+(guanine748-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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