Biology:4-Dimethylallyltryptophan N-methyltransferase

From HandWiki
Short description: Class of enzymes
4-dimethylallyltryptophan N-methyltransferase
Identifiers
EC number2.1.1.261
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

4-dimethylallyltryptophan N-methyltransferase (EC 2.1.1.261, fgaMT (gene), easF (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine

The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.

References

  1. "Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase". The Journal of Biological Chemistry 283 (40): 26859–68. October 2008. doi:10.1074/jbc.m804979200. PMID 18678866. 

External links