Biology:ACOT8

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.[1][2][3][4][5]

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.[5]

References

  1. "Identification of peroxisomal acyl-CoA thioesterases in yeast and humans". J Biol Chem 274 (14): 9216–23. Apr 1999. doi:10.1074/jbc.274.14.9216. PMID 10092594. 
  2. "Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation". J Biol Chem 272 (21): 13779–85. Jul 1997. doi:10.1074/jbc.272.21.13779. PMID 9153233. 
  3. "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res 46 (9): 2029–32. Aug 2005. doi:10.1194/jlr.E500003-JLR200. PMID 16103133. 
  4. "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J 20 (11): 1855–64. Aug 2006. doi:10.1096/fj.06-6042com. PMID 16940157. https://arrow.dit.ie/scschbioart/11. 
  5. 5.0 5.1 "Entrez Gene: ACOT8 acyl-CoA thioesterase 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10005. 

Further reading

External links