Biology:ACTR1B
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Beta-centractin is a protein that in humans is encoded by the ACTR1B gene.[1][2][3]
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins are of equal length and share 90% amino acid identity. They are present in a constant ratio of approximately 1:15 in the dynactin complex.[3]
References
- ↑ "Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins". Mol Biol Cell 5 (12): 1301–10. May 1995. doi:10.1091/mbc.5.12.1301. PMID 7696711.
- ↑ "Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1→q11.2 with somatic cell hybrids and in situ hybridization". Cytogenet Cell Genet 84 (1–2): 48–9. Jun 1999. doi:10.1159/000015211. PMID 10343100.
- ↑ 3.0 3.1 "Entrez Gene: ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10120.
Further reading
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1". Mol. Biol. Cell 14 (7): 2645–54. 2004. doi:10.1091/mbc.E03-01-0049. PMID 12857853.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. 1992. doi:10.1038/355632a0. PMID 1538749. Bibcode: 1992Natur.355..632A.
External links
- ACTR1B human gene location in the UCSC Genome Browser.
- ACTR1B human gene details in the UCSC Genome Browser.
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