Biology:BAAT
From HandWiki
Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.[1]
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.[1]
References
External links
- Human BAAT genome location and BAAT gene details page in the UCSC Genome Browser.
Further reading
- "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver.". J. Biol. Chem. 266 (16): 10227–33. 1991. doi:10.1016/S0021-9258(18)99213-6. PMID 2037576.
- "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase.". J. Biol. Chem. 269 (30): 19375–9. 1994. doi:10.1016/S0021-9258(17)32178-6. PMID 8034703.
- "An EST and STS-based YAC contig map of human chromosome 9q22.3.". Genomics 38 (2): 199–205. 1997. doi:10.1006/geno.1996.0616. PMID 8954802.
- "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts.". J. Lipid Res. 41 (7): 1154–62. 2000. doi:10.1016/S0022-2275(20)32022-8. PMID 10884298.
- "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase.". J. Biol. Chem. 277 (49): 47270–5. 2003. doi:10.1074/jbc.M207463200. PMID 12239217.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.". Nat. Genet. 34 (1): 91–6. 2003. doi:10.1038/ng1147. PMID 12704386.
- "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.". Biochem. Biophys. Res. Commun. 305 (3): 611–8. 2003. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038.
- "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.". J. Biol. Chem. 278 (36): 34237–44. 2003. doi:10.1074/jbc.M300987200. PMID 12810727.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport.". Hepatology 45 (2): 340–8. 2007. doi:10.1002/hep.21528. PMID 17256745.
- "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals.". Drug Metab. Pharmacokinet. 22 (2): 125–8. 2007. doi:10.2133/dmpk.22.125. PMID 17495420.
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