Biology:BICD2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.[1][2]
This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.[2]
Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.
References
- ↑ "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. Dec 1998. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ↑ 2.0 2.1 "Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23299.
Further reading
- Beausoleil SA; Jedrychowski M; Schwartz D; Elias, JE; Villén, J; Li, J; Cohn, MA; Cantley, LC et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- Beausoleil SA; Villén J; Gerber SA; Rush, John; Gygi, Steven P (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Brill LM; Salomon AR; Ficarro SB; Mukherji, Mridul; Stettler-Gill, Michelle; Peters, Eric C (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- "Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes". GTPases Regulating Membrane Targeting and Fusion. Methods in Enzymology. 403. 2005. pp. 607–18. doi:10.1016/S0076-6879(05)03053-3. ISBN 978-0-12-182808-0. https://archive.org/details/gtpasesregulatin403balc/page/607.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Holland PM; Milne A; Garka K; Johnson, RS; Willis, C; Sims, JE; Rauch, CT; Bird, TA et al. (2002). "Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2". J. Biol. Chem. 277 (18): 16229–40. doi:10.1074/jbc.M108662200. PMID 11864968.
- Hoogenraad CC; Akhmanova A; Howell SA; Dortland, BR; De Zeeuw, CI; Willemsen, R; Visser, P; Grosveld, F et al. (2001). "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein–dynactin pathway by interacting with these complexes". EMBO J. 20 (15): 4041–54. doi:10.1093/emboj/20.15.4041. PMID 11483508.
- Hoogenraad CC; Wulf P; Schiefermeier N; Stepanova, T; Galjart, N; Small, JV; Grosveld, F; De Zeeuw, CI et al. (2004). "Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport". EMBO J. 22 (22): 6004–15. doi:10.1093/emboj/cdg592. PMID 14609947.
- Humphray SJ; Oliver K; Hunt AR; Plumb, R. W.; Loveland, J. E.; Howe, K. L.; Andrews, T. D.; Searle, S. et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- Matanis T; Akhmanova A; Wulf P; Del Nery, Elaine; Weide, Thomas; Stepanova, Tatiana; Galjart, Niels; Grosveld, Frank et al. (2003). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383.
- Olsen JV; Blagoev B; Gnad F; Macek, Boris; Kumar, Chanchal; Mortensen, Peter; Mann, Matthias (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Rush J; Moritz A; Lee KA; Guo, Ailan; Goss, Valerie L; Spek, Erik J; Zhang, Hui; Zha, Xiang-Ming et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Short B; Preisinger C; Schaletzky J; Kopajtich, Robert; Barr, Francis A (2003). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. Bibcode: 2002CBio...12.1792S.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
External links
- Human BICD2 genome location and BICD2 gene details page in the UCSC Genome Browser.
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