Biology:Bacterial binding protein-dependent transporter
| BPD_transp_1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BPD_transp_1 | ||||||||
| Pfam | PF00528 | ||||||||
| Pfam clan | CL0404 | ||||||||
| InterPro | IPR000515 | ||||||||
| PROSITE | PDOC00364 | ||||||||
| TCDB | 3.A.1 | ||||||||
| OPM superfamily | 17 | ||||||||
| OPM protein | 3puz | ||||||||
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Bacterial binding protein-dependent transport systems,[1][2] are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport system. The integral inner-membrane proteins translocate the substrate across the membrane. It has been shown,[3][4] that most of these proteins contain a conserved region located about 80 to 100 residues from their C-terminal extremity. This region seems [5] to be located in a cytoplasmic loop between two transmembrane domains. Apart from the conserved region, the sequence of these proteins is quite divergent, and they have a variable number of transmembrane helices, however they can be classified into seven families which have been respectively termed: araH, cysTW, fecCD, hisMQ, livHM, malFG and oppBC.
References
- ↑ Ames GF (1986). "Bacterial periplasmic transport systems: structure, mechanism, and evolution". Annu. Rev. Biochem. 55: 397–425. doi:10.1146/annurev.bi.55.070186.002145. PMID 3527048.
- ↑ "Binding protein-dependent transport systems". J. Bioenerg. Biomembr. 22 (4): 571–92. August 1990. doi:10.1007/BF00762962. PMID 2229036.
- ↑ "Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems". EMBO J. 4 (9): 2287–93. September 1985. doi:10.1002/j.1460-2075.1985.tb03928.x. PMID 3000770.
- ↑ "Bacterial binding protein-dependent permeases: characterization of distinctive signatures for functionally related integral cytoplasmic membrane proteins". Mol. Microbiol. 12 (6): 993–1004. June 1994. doi:10.1111/j.1365-2958.1994.tb01087.x. PMID 7934906.
- ↑ "Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium". Mol. Microbiol. 6 (1): 47–57. January 1992. doi:10.1111/j.1365-2958.1992.tb00836.x. PMID 1738314.
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