Biology:Bomanin
| Bomanin | |||||||
|---|---|---|---|---|---|---|---|
 The fruit fly, Drosophila melanogaster | |||||||
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| Organism | |||||||
| Symbol | Bom | ||||||
| UniProt | P82706 | ||||||
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The Bomanin gene family encodes a group of immune peptides that are essential for Drosophila fruit fly defence against infection by many pathogens.[1][2]
The gene family is named in honour of Hans G. Boman, for his contributions to innate immunity and the discovery of antimicrobial peptides.[1] While Bomanins are essential for survival after infection by many kinds of Gram-positive bacteria and pathogenic fungi, the reason they are key to defence may be because Bomanins promote resilience to pathogen toxins, and not because they directly suppress pathogens.[3] However fly hemolymph (blood) loses its fungicidal activity in the absence of Bomanins, suggesting these peptides are also somehow needed to turn the hemolymph into an antimicrobial environment.[4]
See also
- Hans G. Boman
- Antimicrobial peptides
- Drosomycin
- Metchnikowin
- Baramicin
- Daisho
- The Toll immunity signalling pathway
References
- ↑ 1.0 1.1 "An effector Peptide family required for Drosophila toll-mediated immunity". PLOS Pathogens 11 (4): e1004876. April 2015. doi:10.1371/journal.ppat.1004876. PMID 25915418.
- ↑ "Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach". eLife 8: e44341. February 2019. doi:10.7554/eLife.44341. PMID 30803481.
- ↑ "The Toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific Bomanins". EMBO Reports 24 (1): e56036. January 2023. doi:10.15252/embr.202256036. PMID 36322050.
- ↑ "Short-Form Bomanins Mediate Humoral Immunity in Drosophila". Journal of Innate Immunity 10 (4): 306–314. 2018. doi:10.1159/000489831. PMID 29920489.
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