Chemistry:Daisho (Drosophila peptide)
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Short description: Antimicrobial peptide immune gene of fruit flies
| Daisho (Drosophila peptide) | |||||||
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 The fruit fly, Drosophila melanogaster | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | Dso | ||||||
| UniProt | P82705 | ||||||
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Daisho (Dso) is an antimicrobial peptide gene family of the fruit fly Drosophila melanogaster. Two Daisho genes (Dso1, Dso2) are encoded in tandem in the fruit fly genome, one shorter than the other. This pair of genes with different length was named "Daisho" in reference to Daisho Japanese swords, which come in pairs with one shorter than the other.[1]
The Daisho genes are regulated by Drosophila Toll-like receptor signalling.[2] Daisho peptides protect flies against filamentous fungi, particularly Fusarium and also Aspergillus.[1] Daisho peptides are part of the Drosophila antifungal effector peptide response, which includes the gene families Bomanin, Drosomycin, Metchnikowin, and Baramicin.
References
- ↑ 1.0 1.1 "The Daisho Peptides Mediate Drosophila Defense Against a Subset of Filamentous Fungi". Frontiers in Immunology 11: 9. 2020-01-23. doi:10.3389/fimmu.2020.00009. PMID 32038657.
- ↑ "Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study". Proceedings of the National Academy of Sciences of the United States of America 95 (19): 11342–11347. September 1998. doi:10.1073/pnas.95.19.11342. PMID 9736738. Bibcode: 1998PNAS...9511342U.
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