Biology:Borrelia hermsii
| Borrelia hermsii | |
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| Borrelia hermsii (green) on red blood cells | |
Scientific classification 
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| Domain: | Bacteria |
| Phylum: | Spirochaetota |
| Class: | Spirochaetia |
| Order: | Spirochaetales |
| Family: | Borreliaceae |
| Genus: | Borrelia |
| Species: | B. hermsii
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| Binomial name | |
| Borrelia hermsii (Davis, 1942) Steinhaus, 1946
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Borrelia hermsii is a spirochete bacterium representing the endemic causative agent of tick-borne relapsing fever in eastern regions of North America (more specifically, the eastern United States, and British Columbia region of Canada). It is spread by the soft-bodied tick Ornithodoros hermsi. Human infections characteristically occur among campers and people temporarily lodging in wooden accommodations in proximity to rodents. Human disease is usually relatively mild with low fever.[1]
Epidemiology
B. hermsii is endemic to regions of the U.S. with high elevation (whereas B. turicatae is endemic to low-lying regions such as Texas and Florida).[2]
Borrelia hermsii express a surface protein called FhbA. This protein evades the immune system by binding to FH and FHL-1, which are regulators of the complement system. This prevents the immune system from attacking bacteria. The FhbA is a surface-exposed lipoprotein that encodes for a single-genetic locus. It has a high affinity for binding to FH and recombinant FH. It has an important role in bacterial survival and therefore can be used for diagnosis- FhbA genes are mingled with majority of relapsing fever clade. [3]
References
- ↑ "Dictionnaire médical de l'Académie de Médecine". https://www.academie-medecine.fr/le-dictionnaire/index.php?q=Borrelia+hermsii.
- ↑ "Relapsing Fever - Infectious Diseases" (in en). https://www.msdmanuals.com/professional/infectious-diseases/spirochetes/relapsing-fever.
- ↑ Guérin, Mickaël; Vandevenne, Marylène; Brans, Alain; Matagne, André; Marquant, Rodrigue; Prost, Elise; Octave, Stéphane; Avalle, Bérangère et al. (December 2024). "Production, purification, and quality assessment of borrelial proteins CspZ from Borrelia burgdorferi and FhbA from Borrelia hermsii". Applied Microbiology and Biotechnology 108 (1): 1-14. doi:10.1007/s00253-024-13195-2.
Wikidata ☰ Q4946575 entry
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