Biology:C8 complex
From HandWiki
Short description: Protein involved in the complement system
Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC).
A hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea.
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Structure
C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the genes C8A, C8B and C8G respectively.
References
- ↑ PDB: 3OJY; "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement". The Journal of Biological Chemistry 286 (20): 17585–92. May 2011. doi:10.1074/jbc.M111.219766. PMID 21454577.
External links
- Complement+C8 at the US National Library of Medicine Medical Subject Headings (MeSH)
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