Biology:C3a receptor
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.[1][2]
The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.[3] C3a receptor modulates immunity,[4] arthritis, diet-induced obesity[5] and cancers.[6]
Agonists and antagonists
Potent and selective agonists[7] and antagonists[8] for C3aR have been discovered.
References
- ↑ "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1305 (1–2): 39–43. February 1996. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
- ↑ "Anaphylatoxin C3a receptors in asthma". Respiratory Research 6 (1): 19. February 2005. doi:10.1186/1465-9921-6-19. PMID 15723703.
- ↑ "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews 65 (1): 500–43. January 2013. doi:10.1124/pr.111.005223. PMID 23383423.
- ↑ "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation 13 (10): 2530–9. October 2013. doi:10.1111/ajt.12405. PMID 24033923.
- ↑ "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal 27 (2): 822–31. February 2013. doi:10.1096/fj.12-220582. PMID 23118029.
- ↑ "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine 3 (4): 747–58. August 2014. doi:10.1002/cam4.241. PMID 24711204.
- ↑ "Downsizing a human inflammatory protein to a small molecule with equal potency and functionality". Nature Communications 4: 2802. 2013. doi:10.1038/ncomms3802. PMID 24257095. Bibcode: 2013NatCo...4.2802R.
- ↑ "Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides". Journal of the American Chemical Society 136 (34): 11914–7. August 2014. doi:10.1021/ja506518t. PMID 25102224.
Further reading
- "Serine proteases of the complement system". Biochemical Society Transactions 28 (5): 545–50. October 2000. doi:10.1042/bst0280545. PMID 11044372.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1305 (1–2): 39–43. February 1996. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
- "Molecular cloning and characterization of the human anaphylatoxin C3a receptor". The Journal of Biological Chemistry 271 (34): 20231–4. August 1996. doi:10.1074/jbc.271.34.20231. PMID 8702752.
- "Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells". European Journal of Immunology 26 (8): 1944–50. August 1996. doi:10.1002/eji.1830260840. PMID 8765043.
- "In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins". FEBS Letters 395 (2–3): 157–9. October 1996. doi:10.1016/0014-5793(96)01018-6. PMID 8898085.
- "The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes". The Journal of Experimental Medicine 186 (2): 199–207. July 1997. doi:10.1084/jem.186.2.199. PMID 9221749.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene". Molecular Immunology 35 (3): 137–48. February 1998. doi:10.1016/S0161-5890(98)00021-2. PMID 9694514.
- "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor". Journal of Immunology 161 (5): 2089–93. September 1998. doi:10.4049/jimmunol.161.5.2089. PMID 9725198.
- "Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells". Glia 26 (3): 201–11. May 1999. doi:10.1002/(SICI)1098-1136(199905)26:3<201::AID-GLIA2>3.0.CO;2-M. PMID 10340761.
- "Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a". Journal of Immunology 162 (12): 7409–16. June 1999. doi:10.4049/jimmunol.162.12.7409. PMID 10358194.
- "Cloning and characterization of a rabbit ortholog of human Galpha16 and mouse G(alpha)15". FEBS Letters 460 (1): 53–6. October 1999. doi:10.1016/S0014-5793(99)01317-4. PMID 10571060.
- "Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a". Journal of Immunology 164 (7): 3783–9. April 2000. doi:10.4049/jimmunol.164.7.3783. PMID 10725738.
- "Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma". Journal of Immunology 166 (3): 2025–32. February 2001. doi:10.4049/jimmunol.166.3.2025. PMID 11160252.
- "Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models". Journal of Immunology 166 (10): 6341–8. May 2001. doi:10.4049/jimmunol.166.10.6341. PMID 11342658.
- "Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin". Immunology 103 (2): 210–7. June 2001. doi:10.1046/j.1365-2567.2001.01197.x. PMID 11412308.
- "Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1". Blood 101 (10): 3784–93. May 2003. doi:10.1182/blood-2002-10-3233. PMID 12511407.
External links
- "Anaphylatoxin Receptors: C3a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2973.
- C3AR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human C3AR1 genome location and C3AR1 gene details page in the UCSC Genome Browser.
 |  |
