Biology:MASP2 (protein)

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Mannan-binding lectin serine protease 2 also known as mannose-binding protein-associated serine protease 2 (MASP-2) is an enzyme that in humans is encoded by the MASP2 gene.

Function

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.

MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.

See also

• MASP1 (protein)
• Mannan-binding lectin
• Mannan-binding lectin pathway (lectin pathway)

Further reading

• "The mannan-binding lectin pathway of complement activation: biology and disease association". Mol. Immunol. 38 (2–3): 133–49. 2001. doi:10.1016/S0161-5890(01)00038-4. PMID 11532276. 
• "Common variation in genes related to innate immunity and risk of adult glioma.". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. 2009. doi:10.1158/1055-9965.EPI-08-1041. PMID 19423540. 
• "Integrative predictive model of coronary artery calcification in atherosclerosis.". Circulation 120 (24): 2448–54. 2009. doi:10.1161/CIRCULATIONAHA.109.865501. PMID 19948975. 
• "Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot.". Immunology 129 (4): 482–95. 2010. doi:10.1111/j.1365-2567.2009.03200.x. PMID 20002787. 
• "Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.". Br. J. Haematol. 145 (5): 614–23. 2009. doi:10.1111/j.1365-2141.2009.07675.x. PMID 19344414. 
• "Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection.". BMC Infect. Dis. 9: 51. 2009. doi:10.1186/1471-2334-9-51. PMID 19405982. 
• "Polymorphisms in innate immunity genes and risk of childhood leukemia.". Hum. Immunol. 71 (7): 727–30. 2010. doi:10.1016/j.humimm.2010.04.004. PMID 20438785. 
• "Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation.". J. Immunol. 185 (7): 4169–78. 2010. doi:10.4049/jimmunol.1001819. PMID 20817870. 
• "Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.". J. Gastroenterol. Hepatol. 24 (12): 1840–6. 2009. doi:10.1111/j.1440-1746.2009.06009.x. PMID 19817957. 
• "Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome.". Clin. Vaccine Immunol. 17 (3): 447–53. 2010. doi:10.1128/CVI.00375-09. PMID 20042521. 
• "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. 2009. doi:10.1016/j.ajhg.2009.10.014. PMID 19913121. 
• "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer.". Scand. J. Immunol. 73 (2): 122–7. 2011. doi:10.1111/j.1365-3083.2010.02480.x. PMID 21198752. 
• "Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency.". Eur. Respir. J. 36 (4): 856–63. 2010. doi:10.1183/09031936.00171409. PMID 20150204. 
• "Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation.". Hepatology 52 (3): 1100–10. 2010. doi:10.1002/hep.23782. PMID 20593422. 
• "Risk of meningioma and common variation in genes related to innate immunity.". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. 2010. doi:10.1158/1055-9965.EPI-09-1151. PMID 20406964. 
• "[Study on interaction between SARS-CoV N and MAP19].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 (9): 777–9. 2009. PMID 19737459. 
• "Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations". Mol. Immunol. 46 (8–9): 1696–701. 2009. doi:10.1016/j.molimm.2009.02.022. PMID 19307021. 
• "Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children.". Tissue Antigens 74 (4): 298–307. 2009. doi:10.1111/j.1399-0039.2009.01328.x. PMID 19775369. 
• "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. 2010. doi:10.2337/dc10-0452. PMID 20628086. 

External links

• MASP+Proteases at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.