Biology:CAMK4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca²⁺/calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.

Further reading

• "Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites". J. Biol. Chem. 267 (16): 10976–81. 1992. doi:10.1016/S0021-9258(19)49862-1. PMID 1375933. 
• "Nuclear and axonal localization of Ca²⁺/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2850–3. 1991. doi:10.1073/pnas.88.7.2850. PMID 2011593. Bibcode: 1991PNAS...88.2850J. 
• "Phosphorylation and activation of Ca²⁺-calmodulin-dependent protein kinase IV by Ca²⁺-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation". J. Biol. Chem. 270 (29): 17616–21. 1995. doi:10.1074/jbc.270.29.17616. PMID 7615569. 
• "cDNA cloning and expression of human calmodulin-dependent protein kinase IV". J. Biochem. 115 (4): 637–40. 1994. doi:10.1093/oxfordjournals.jbchem.a124387. PMID 8089075. 
• "A Ca²⁺/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1". J. Virol. 68 (3): 1697–705. 1994. doi:10.1128/JVI.68.3.1697-1705.1994. PMID 8107230. 
• "The cDNA sequence and characterization of the Ca²⁺/calmodulin-dependent protein kinase-Gr from human brain and thymus". Gene 142 (2): 191–7. 1994. doi:10.1016/0378-1119(94)90260-7. PMID 8194751. 
• "Requirements for calcium and calmodulin in the calmodulin kinase activation cascade". J. Biol. Chem. 271 (10): 5617–22. 1996. doi:10.1074/jbc.271.10.5617. PMID 8621423. 
• "A unique phosphorylation-dependent mechanism for the activation of Ca²⁺/calmodulin-dependent protein kinase type IV/GR". J. Biol. Chem. 271 (35): 21542–8. 1996. doi:10.1074/jbc.271.35.21542. PMID 8702940. 
• "Regulation of microtubule dynamics by Ca²⁺/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18". Mol. Cell. Biol. 17 (6): 3459–67. 1997. doi:10.1128/mcb.17.6.3459. PMID 9154845. 
• "Characterization of the mechanism of regulation of Ca²⁺/ calmodulin-dependent protein kinase I by calmodulin and by Ca²⁺/calmodulin-dependent protein kinase kinase". J. Biol. Chem. 273 (34): 21473–81. 1998. doi:10.1074/jbc.273.34.21473. PMID 9705275. 
• "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca²⁺/calmodulin-dependent protein kinase kinase beta". J. Biol. Chem. 273 (48): 31880–9. 1998. doi:10.1074/jbc.273.48.31880. PMID 9822657. 
• "Regulation of neuronal nitric-oxide synthase by calmodulin kinases". J. Biol. Chem. 274 (29): 20597–602. 1999. doi:10.1074/jbc.274.29.20597. PMID 10400690. 
• "Ca²⁺-dependent gene expression mediated by MEF2 transcription factors". J. Biol. Chem. 275 (1): 197–209. 2000. doi:10.1074/jbc.275.1.197. PMID 10617605. 
• "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". J. Biol. Chem. 275 (8): 5257–63. 2000. doi:10.1074/jbc.275.8.5257. PMID 10681496. 
• "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells". J. Biol. Chem. 275 (36): 28139–43. 2000. doi:10.1074/jbc.M003198200. PMID 10874031. 
• "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet. 25 (4): 448–52. 2000. doi:10.1038/78153. PMID 10932193. 
• "Ca²⁺/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit". J. Biol. Chem. 276 (23): 20005–10. 2001. doi:10.1074/jbc.M010211200. PMID 11274168. 
• "Human Ca²⁺/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity". J. Biol. Chem. 276 (33): 31113–23. 2001. doi:10.1074/jbc.M011720200. PMID 11395482. 
• "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking". J. Biol. Chem. 276 (37): 35042–8. 2001. doi:10.1074/jbc.M105086200. PMID 11470791. 
• Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb et al. (2008). "Loss of the Ca²⁺/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine". Proceedings of the National Academy of Sciences of the United States of America (PNAS) 105 (45): 17549–54. doi:10.1073/pnas.0803959105. PMID 19001277. Bibcode: 2008PNAS..10517549B. 
• "Repression of Ca²⁺/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells.". J. Biol. Chem. 284 (39): 26466–81. 2009. doi:10.1074/jbc.M109.027680. PMID 19633294. 

External links

• Human CAMK4 genome location and CAMK4 gene details page in the UCSC Genome Browser.