Biology:CLSTN1
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Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.[1][2]
Clinical relevance
Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.[3]
Interactions
CLSTN1 has been shown to interact with APBA2[4][5] and Amyloid precursor protein.[4][5]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. Dec 1998. doi:10.1093/dnares/5.6.355. PMID 10048485.
- ↑ "Entrez Gene: CLSTN1 calsyntenin 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22883.
- ↑ "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics 21 (13): 2845–54. Jul 2012. doi:10.1093/hmg/dds109. PMID 22434822.
- ↑ 4.0 4.1 "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry 278 (49): 49448–58. Dec 2003. doi:10.1074/jbc.M306024200. PMID 12972431.
- ↑ 5.0 5.1 "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry 279 (23): 24343–54. Jun 2004. doi:10.1074/jbc.M401925200. PMID 15037614.
External links
- Human CLSTN1 genome location and CLSTN1 gene details page in the UCSC Genome Browser.
- Human PIK3CD genome location and PIK3CD gene details page in the UCSC Genome Browser.
Further reading
- "Calsyntenin-1 docks vesicular cargo to kinesin-1". Molecular Biology of the Cell 17 (8): 3651–63. Aug 2006. doi:10.1091/mbc.E06-02-0112. PMID 16760430. PMC 1525238. http://www.zora.uzh.ch/1134/1/KonecnaSonderegger2006V.pdf.
- "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology 22 (6): 724–31. Jun 2004. doi:10.1038/nbt969. PMID 15146195.
- "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry 279 (23): 24343–54. Jun 2004. doi:10.1074/jbc.M401925200. PMID 15037614.
- "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry 278 (49): 49448–58. Dec 2003. doi:10.1074/jbc.M306024200. PMID 12972431.
- "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research 12 (11): 1773–84. Nov 2002. doi:10.1101/gr.406902. PMID 12421765.
- "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Molecular and Cellular Neurosciences 17 (1): 151–66. Jan 2001. doi:10.1006/mcne.2000.0937. PMID 11161476.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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