Biology:CYB561
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 Generic protein structure example |
Cytochrome b561 is a protein that in humans is encoded by the CYB561 gene.[1][2]
Model organisms
| Characteristic | Phenotype |
|---|---|
| Homozygote viability | Normal |
| Fertility | Normal |
| Body weight | Normal |
| Anxiety | Normal |
| Neurological assessment | Normal |
| Grip strength | Normal |
| Hot plate | Normal |
| Dysmorphology | Normal[3] |
| Indirect calorimetry | Normal |
| Glucose tolerance test | Abnormal[4] |
| Auditory brainstem response | Normal |
| DEXA | Normal |
| Radiography | Normal |
| Body temperature | Normal |
| Eye morphology | Normal |
| Clinical chemistry | Normal |
| Haematology | Normal |
| Peripheral blood lymphocytes | Normal |
| Micronucleus test | Normal |
| Heart weight | Normal |
| Eye Histopathology | Normal |
| Salmonella infection | Normal[5] |
| Citrobacter infection | Normal[6] |
| All tests and analysis from[7][8] |
Model organisms have been used in the study of CYB561 function. A conditional knockout mouse line, called Cyb561tm1a(EUCOMM)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[11][12][13]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty three tests were carried out on mutant mice and one significant abnormality was observed: female homozygotes displayed a decreased circulating glucose level after a glucose tolerance test.[7]
References
- ↑ "The human cytochrome b561 gene (CYB561) is located at 17q11-qter". Genomics 21 (3): 662–3. Nov 1994. doi:10.1006/geno.1994.1332. PMID 7959749. https://zenodo.org/record/1229636.
- ↑ "Entrez Gene: CYB561 cytochrome b-561". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1534.
- ↑ "Dysmorphology data for Cyb561". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MALD/dysmorphology/.
- ↑ "Glucose tolerance test data for Cyb561". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MALD/glucose-tolerance-ip/.
- ↑ "Salmonella infection data for Cyb561". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MALD/salmonella-challenge/.
- ↑ "Citrobacter infection data for Cyb561". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MALD/citrobacter-challenge/.
- ↑ 7.0 7.1 7.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
- ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
- ↑ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Cyb561.
- ↑ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432734.
- ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.
- ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
- ↑ "A Mouse for All Reasons". Cell 128 (1): 9–13. 2007. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
- ↑ "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. 2011. doi:10.1186/gb-2011-12-6-224. PMID 21722353.
External links
- Human CYB561 genome location and CYB561 gene details page in the UCSC Genome Browser.
Further reading
- "Isolation and properties of cytochrome b561 from bovine adrenal chromaffin granules.". J. Biol. Chem. 257 (15): 8561–4. 1982. doi:10.1016/S0021-9258(18)34156-5. PMID 7096323.
- Srivastava M (1995). "Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane.". J. Biol. Chem. 270 (39): 22714–20. doi:10.1074/jbc.270.39.22714. PMID 7559396.
- "Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information". Biochem. J. 303 (Pt 3): 915–21. 1994. doi:10.1042/bj3030915. PMID 7980462.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Structure prediction for the di-heme cytochrome b561 protein family". Protoplasma 221 (1–2): 31–40. 2004. doi:10.1007/s00709-002-0065-0. PMID 12768339.
- "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. 2003. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283.
- "Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases". Biochim. Biophys. Acta 1651 (1–2): 116–23. 2003. doi:10.1016/S1570-9639(03)00242-5. PMID 14499595.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
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