Biology:Cryptococcus

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Short description: Genus of fungi
Do not confuse Cryptococcus (fungi) with Cryptosporidium (protists).

Cryptococcus
Cryptococcus neoformans using a light India ink staining preparation PHIL 3771 lores.jpg
Yeast state of Cryptococcus neoformans
Scientific classification e
Domain: Eukaryota
Kingdom: Fungi
Division: Basidiomycota
Class: Tremellomycetes
Order: Tremellales
Family: Cryptococcaceae
Genus: Cryptococcus
Vuill. (1901)
Type species
Cryptococcus neoformans
Species

Cryptococcus amylolentus
C. bacillisporus
C. decagattii
C. deneoformans
C. depauperatus
C. deuterogattii
C. gattii
C. luteus
C. tetragattii

Synonyms

Filobasidiella Kwon-Chung (1975) Tsuchiyaea Y. Yamada, H. Kawas., Itoh, I. Banno & Nakase (1988)

Cryptococcus is a genus of fungi in the family Cryptococcaceae that includes both yeasts and filamentous species. The filamentous, sexual forms or teleomorphs were formerly classified in the genus Filobasidiella, while Cryptococcus was reserved for the yeasts. Most yeast species formerly referred to Cryptococcus have now been placed in different genera. The name Cryptococcus comes from the Greek for "hidden sphere" (literally "hidden berry"). Some Cryptococcus species cause a disease called cryptococcosis.

Taxonomy

The genus was described by French mycologist Jean Paul Vuillemin in 1901, when he failed to find ascospores characteristic of the genus Saccharomyces in the yeast previously known as Saccharomyces neoformans.[1] Over 300 additional names were subsequently added to the genus, almost all of which were later removed following molecular research based on cladistic analysis of DNA sequences. As a result, some ten species are currently recognized in Cryptococcus.[2]

The teleomorph was first described in 1975 by K.J. Kwon-Chung, who obtained cultures of the type species, Filobasidiella neoformans, by crossing strains of the yeast Cryptococcus neoformans. She was able to observe basidia similar to those of the genus Filobasidium, hence the name Filobasidiella for the new genus.[3] Following changes to the International Code of Nomenclature for algae, fungi, and plants, the practice of giving different names to teleomorph and anamorph forms of the same fungus was discontinued, meaning that Filobasidiella became a synonym of the earlier name Cryptococcus.

General characteristics

The cells of species that produce yeasts are covered in a thin layer of glycoprotein capsular material that has a gelatin-like consistency, and that among other functions, serves to help extract nutrients from the soil. The C. neoformans capsule consists of several polysaccharides, of which the major one is the immunomodulatory polysaccharide called glucuronoxylomannan (GXM).[4] GXM is made up of the monosaccharides glucuronic acid, xylose and mannose and can also contain O-acetyl groups. The capsule functions as the major virulence factor in cryptococcal infection and disease.[5]

Some Cryptococcus species have a huge diversity at the infraspecific level with different molecular types based on their genetic differences, mainly due to their geographical distribution, molecular characteristics, and ecological niches.[6]

Cryptococcus species are not known to produce distinct, visible fruitbodies. All teleomorph forms appear to be parasites of other fungi. In teleomorphs the hyphae are colourless, are clamped or unclamped, and bear haustorial cells with filaments that attach to the hyphae of host fungi.[7][8] The basidia are club-shaped and highly elongated. Spores arise in succession from four loci at the apex (which is sometimes partly septate). These spores are passively released and may remain on the basidium in chains, unless disturbed.[3] In the type species, the spores germinate to form yeast cells, but yeast states are not known for all species.

Habitat, distribution and species

Field stain showing Cryptococcus species in lung tissue

Main page: Cryptococcus neoformans

Cryptococcus neoformans is cosmopolitan and is the most prominent medically important species. It is best known for causing a severe form of meningitis and meningoencephalitis in people with HIV/AIDS. It may also infect organ-transplant recipients and people receiving certain cancer treatments.[9] In its yeast state C. neoformans is found in the droppings of wild birds, often pigeons; when dust of the droppings is stirred up, it can infect humans or pets that inhale the dust. Infected humans and animals do not transmit their infection to others.[9] The taxonomy of C. neoformans has been reviewed: it has now been divided into two species: Cryptococcus neoformans sensu stricto and Cryptococcus deneoformans.[10][2]

Main page: Cryptococcus gattii

Cryptococcus gattii (formerly C. neoformans var. gattii) is endemic to tropical parts of the continent of Africa and Australia. It is capable of causing disease in non-immunocompromised people. In its yeast state it has been isolated from eucalyptus trees in Australia. The taxonomy of C. gattii has been reviewed; it has now been divided into five species: C. gattii sensu stricto, C. bacillisporus, 'C. deuterogattii, C. tetragattii, and C. decagattii.[10][2]

Cryptococcus depauperatus is parasitic on Lecanicillium lecanii, an entomopathogenic fungus, and is known from Sri Lanka, England, the Netherlands, the Czech Republic, and Canada.[8][11] It is not known to produce a yeast state.[12] This species grows as long, branching filaments and is self-fertile, i.e. it is homothallic.[13] It can reproduce sexually with itself throughout its life cycle.[13]

Cryptococcus luteus is parasitic on Granulobasidium vellereum, a corticioid fungus, and is known from England and Italy.[14] It too is not known to produce a yeast state.[15]

Cryptococcus amylolentus was originally isolated as a yeast from beetle tunnels in South African trees. It forms a basidia-bearing teleomorph in culture.[16]

References

  1. ↑ Kurtzman, Cletus P.; Fell, Jack W. (20 March 1998). The Yeasts - A Taxonomic Study. Elsevier. ISBN 9780080542690. https://books.google.com/books?id=bnWQsv2eTcEC&dq=%22Saccharomyces+neoformans%22&pg=PA660. 
  2. ↑ 2.0 2.1 2.2 "Towards an integrated phylogenetic classification of the Tremellomycetes". Studies in Mycology 81: 85–147. 2015. doi:10.1016/j.simyco.2015.12.001. PMID 26955199. 
  3. ↑ 3.0 3.1 Kwon-Chung KJ. (1975). "A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans". Mycologia 67 (6): 1197–1200. doi:10.2307/3758842. PMID 765816. 
  4. ↑ "The Cryptococcus neoformans cap10 and cap59 mutant strains, affected in glucuronoxylomannan synthesis, differentially activate human dendritic cells". FEMS Immunology and Medical Microbiology 57 (2): 142–50. November 2009. doi:10.1111/j.1574-695X.2009.00587.x. PMID 19694810. 
  5. ↑ Cryptococcus neoformans. American Society for Microbiology, ASM Press. 1998. 
  6. ↑ "Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types". Scientifica 2013: 675213. 2013. doi:10.1155/2013/675213. PMID 24278784. 
  7. ↑ "Phylogeny and phenotypic characterization of pathogenic Cryptococcus species and closely related saprobic taxa in the Tremellales". Eukaryotic Cell 8 (3): 353–361. 2009. doi:10.1128/EC.00373-08. PMID 19151324. 
  8. ↑ 8.0 8.1 "Filobasidiella depauperata (Tremellales): haustorial branches and parasitism of Verticillium lecanii". Mycological Progress 2 (2): 137–140. 2003. doi:10.1007/s11557-006-0051-6. 
  9. ↑ 9.0 9.1 "What is Cryptococcus infection (cryptococcosis)?". Center for Disease Control and Prevention. April 28, 2010. https://www.cdc.gov/healthypets/diseases/crptococcus.htm. 
  10. ↑ 10.0 10.1 "Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex". Fungal Genetics and Biology 78: 16–48. 2015. doi:10.1016/j.fgb.2015.02.009. PMID 25721988. 
  11. ↑ "On the taxonomy of the entomogenous fungus Filobasidiella arachnophila". Antonie van Leeuwenhoek 49 (4–5): 447–456. 1983. doi:10.1007/BF00399323. PMID 6651289. https://link.springer.com/article/10.1007/BF00399323. 
  12. ↑ "Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic Cryptococcus species complex". PLOS ONE 5 (3): e9620. 2010. doi:10.1371/journal.pone.0009620. PMID 20224779. Bibcode: 2010PLoSO...5.9620R. 
  13. ↑ 13.0 13.1 Passer, A. R.; Clancey, S. A.; Shea, T.; David-Palma, M.; Averette, A. F.; Boekhout, T.; Porcel, B. M.; Nowrousian, M. et al. (2022). "Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex". eLife 11. doi:10.7554/eLife.79114. PMID 35713948. 
  14. ↑ "Filobasidiella lutea: parasitism of Hypochnicium vellereum". Karstenia 40 (1–2): 49–51. 2000. doi:10.29203/ka.2000.351. 
  15. ↑ "Genetic relatedness among Filobasidiella species". Mycopathologia 156 (3): 157–162. 2002. doi:10.1023/A:1023309311643. PMID 12749578. 
  16. ↑ "Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex". PLOS Genetics 8 (2): e1002528. 2012. doi:10.1371/journal.pgen.1002528. PMID 22359516. 

Wikidata ☰ Q309498 entry



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