Biology:Cyclin H
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cyclin-H is a protein that in humans is encoded by the CCNH gene.[1][2]
Function
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.[2]
Interactions
Cyclin H has been shown to interact with P53,[3] Cyclin-dependent kinase 7[4][5][6] and MNAT1.[7][8]
References
- ↑ "Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively". Genomics 47 (1): 115–20. Jan 1998. doi:10.1006/geno.1997.5053. PMID 9465303.
- ↑ 2.0 2.1 "Entrez Gene: CCNH cyclin H". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=902.
- ↑ "Regulation of CAK kinase activity by p53". Oncogene 17 (21): 2733–41. November 1998. doi:10.1038/sj.onc.1202504. PMID 9840937.
- ↑ "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. Sep 1994. doi:10.1038/371254a0. PMID 8078587. Bibcode: 1994Natur.371..254M.
- ↑ "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Research 55 (24): 6058–62. December 1995. PMID 8521393.
- ↑ "CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA". Molecular and Cellular Biology 20 (18): 6958–69. Sep 2000. doi:10.1128/MCB.20.18.6958-6969.2000. PMID 10958691.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- ↑ "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". The Journal of Biological Chemistry 278 (13): 11676–85. Mar 2003. doi:10.1074/jbc.M209570200. PMID 12527756.
Further reading
- "Tat, Tat-associated kinase, and transcription". Journal of Biomedical Science 5 (1): 24–7. 1998. doi:10.1007/BF02253352. PMID 9570510.
- "Transcriptional control: Tat cofactors and transcriptional elongation". Current Biology 8 (13): R447–9. Jun 1998. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670.
- "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature 374 (6519): 283–7. Mar 1995. doi:10.1038/374283a0. PMID 7533895. Bibcode: 1995Natur.374..283S.
- "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase". Oncogene 9 (11): 3127–38. November 1994. PMID 7936635.
- "Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK". Cell 79 (6): 1103–9. December 1994. doi:10.1016/0092-8674(94)90040-X. PMID 8001136.
- "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell 78 (4): 713–24. Aug 1994. doi:10.1016/0092-8674(94)90535-5. PMID 8069918.
- "A cyclin associated with the CDK-activating kinase MO15". Nature 371 (6494): 254–7. Sep 1994. doi:10.1038/371254a0. PMID 8078587. Bibcode: 1994Natur.371..254M.
- "Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain". Oncogene 9 (1): 211–9. Jan 1994. PMID 8302582.
- "In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein". The EMBO Journal 14 (22): 5608–17. November 1995. doi:10.1002/j.1460-2075.1995.tb00248.x. PMID 8521818.
- "MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH". The EMBO Journal 15 (8): 1877–84. Apr 1996. doi:10.1002/j.1460-2075.1996.tb00538.x. PMID 8617234.
- "Three functional classes of transcriptional activation domain". Molecular and Cellular Biology 16 (5): 2044–55. May 1996. doi:10.1128/MCB.16.5.2044. PMID 8628270.
- "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6482–7. Jun 1996. doi:10.1073/pnas.93.13.6482. PMID 8692841. Bibcode: 1996PNAS...93.6482R.
- "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes". Proceedings of the National Academy of Sciences of the United States of America 93 (13): 6488–93. Jun 1996. doi:10.1073/pnas.93.13.6488. PMID 8692842. Bibcode: 1996PNAS...93.6488D.
- "Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase". Nature Structural Biology 3 (10): 849–55. Oct 1996. doi:10.1038/nsb1096-849. PMID 8836101.
- "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science 274 (5287): 605–10. Oct 1996. doi:10.1126/science.274.5287.605. PMID 8849451. Bibcode: 1996Sci...274..605Z.
- "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature 384 (6607): 375–8. Nov 1996. doi:10.1038/384375a0. PMID 8934526. Bibcode: 1996Natur.384..375P.
- "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". The Journal of Biological Chemistry 272 (11): 6951–8. Mar 1997. doi:10.1074/jbc.272.11.6951. PMID 9054383.
- "Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH". Protein Expression and Purification 9 (2): 153–8. Mar 1997. doi:10.1006/prep.1996.0693. PMID 9056480.
- "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". The EMBO Journal 16 (5): 1093–102. Mar 1997. doi:10.1093/emboj/16.5.1093. PMID 9118947.
- "The structure of cyclin H: common mode of kinase activation and specific features". The EMBO Journal 16 (5): 958–67. Mar 1997. doi:10.1093/emboj/16.5.958. PMID 9118957.
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